The development of 11C-carbonylation chemistry: A systematic view.

Nuclear Medicine and Biology
Jonas ErikssonOleksiy Itsenko

Abstract

The prospects for using carbon-11 labelled compounds in molecular imaging has improved with the development of diverse synthesis methods, including 11C-carbonylations and refined techniques to handle [11C]carbon monoxide at a nanomole scale. Facilitating biological research and molecular imaging was the driving force when [11C]carbon monoxide was used in the first in vivo application with carbon-11 in human (1945) and when [11C]carbon monoxide was used for the first time as a chemical reagent in the synthesis of [11C]phosgene (1978). This review examines a rich plethora of labelled compounds synthesized from [11C]carbon monoxide, their chemistry and use in molecular imaging. While the strong development of the 11C-carbonylation chemistry has expanded the carbon-11 domain considerably, it could be argued that the number of 11C-carbonyl compounds entering biological investigations should be higher. The reason for this may partly be the lack of commercially available synthesis instruments designed for 11C-carbonylations. But as this review shows, novel and greatly simplified methods to handle [11C]carbon monoxide have been developed. The next important challenge is to make full use of these technologies and synthesis methods in PE...Continue Reading

References

Nov 1, 1971·The International Journal of Applied Radiation and Isotopes·J C Clark, P D Buckingham
Nov 1, 1983·The International Journal of Applied Radiation and Isotopes·C CrouzelD Comar
Jan 1, 1982·International Journal of Nuclear Medicine and Biology·M DiksicS Farrokhzad
Sep 1, 1980·The International Journal of Applied Radiation and Isotopes·C CrouzelD Comar
Nov 1, 2000·Nuclear Medicine and Biology·A A WilsonS Houle
Apr 4, 2002·Nuclear Medicine and Biology·Ken-ichi NishijimaNagara Tamaki
May 25, 2002·The Journal of Organic Chemistry·Tor KihlbergBengt Långström
Nov 16, 2002·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·M W Nader, F Oberdorfer
Nov 28, 2002·Nuclear Medicine and Biology·Eric D Hostetler, H Donald Burns
Apr 26, 2003·The Journal of Organic Chemistry·Obaidur RahmanBengt Långström
Aug 21, 2003·Organic & Biomolecular Chemistry·Farhad Karimi, Bengt Långström
Feb 20, 2004·Chemical Communications : Chem Comm·Helene AudrainDirk Bender
May 27, 2004·Organic & Biomolecular Chemistry·Obaidur RahmanBengt Långstrom
Jun 19, 2004·The Journal of Organic Chemistry·Oleksiy ItsenkoBengt Långström
Mar 12, 2005·The Journal of Organic Chemistry·Oleksiy Itsenko, Bengt Långström
Oct 8, 2005·Organic Letters·Oleksiy Itsenko, Bengt Långström
Nov 25, 2005·Cephalalgia : an International Journal of Headache·R YatesA Dane
Jan 13, 2006·Journal of Pharmacokinetics and Pharmacodynamics·Mats BergströmBengt Långström
Apr 5, 2007·Nature Protocols·Oleksiy ItsenkoBengt Långström
Jul 5, 2007·Journal of the American Chemical Society·Oleksiy ItsenkoChryssostomos Chatgilialoglu
May 12, 2009·Angewandte Chemie·Anne BrennführerMatthias Beller
Jun 27, 2009·Chemical Communications : Chem Comm·Steven KealeyAntony D Gee
Dec 1, 1945·The American Journal of Physiology·C A TOBIAS, J H LAWRENCE
Jan 6, 2011·Chemistry : a European Journal·Philip W MillerRamon Vilar
Feb 15, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Chloe R ChildNicholas J Long
Oct 21, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Christopher W TateNicholas J Long
Oct 21, 2011·International Journal of Molecular Imaging·Orjan LindheGunnar Antoni
Mar 26, 2013·Nuclear Medicine and Biology·Alex J PootAlbert D Windhorst
Dec 12, 2013·Journal of Labelled Compounds & Radiopharmaceuticals·Steven KealeyJan Passchier
Jan 16, 2014·Journal of Labelled Compounds & Radiopharmaceuticals·Steven KealeyPhilip W Miller
May 27, 2014·Nuclear Medicine and Biology·Patrik NordemanGunnar Antoni
Oct 11, 2012·ACS Medicinal Chemistry Letters·Misato Takashima-HiranoMasaaki Suzuki
Jul 6, 2014·Journal of Labelled Compounds & Radiopharmaceuticals·Sara BergmanGunnar Antoni
Jan 9, 2015·Journal of the American Chemical Society·Thomas L AndersenTroels Skrydstrup
Feb 17, 2015·Journal of Labelled Compounds & Radiopharmaceuticals·Gunnar Antoni
Feb 18, 2015·Journal of Labelled Compounds & Radiopharmaceuticals·Obaidur Rahman

❮ Previous
Next ❯

Citations

Jul 30, 2020·Journal of Labelled Compounds & Radiopharmaceuticals·Kenneth DahlNeil Vasdev
Dec 11, 2020·Chemical Communications : Chem Comm·Hugo HelbertPhilip H Elsinga
Jan 29, 2021·EJNMMI Radiopharmacy and Chemistry·Mohammed Al-QahtaniDanielle Vugts
Jun 18, 2020·Nuclear Medicine and Biology·Toshimitsu FukumuraMing-Rong Zhang
Jan 28, 2021·Journal of Medicinal Chemistry·Nerella Sridhar GoudPardeep Kumar
Jun 17, 2021·Chemical Communications : Chem Comm·Victor BabinDavide Audisio
Jul 21, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Morgan CormierPhilippe Hermange

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
S Ram, R L Ehrenkaufer
Kaku igaku. The Japanese journal of nuclear medicine
F ShishidoH Ikehira
Kaku igaku. The Japanese journal of nuclear medicine
F ShishidoT Takashima
Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Sara RoslinJonas Eriksson
© 2021 Meta ULC. All rights reserved