PMID: 9539575Apr 16, 1998Paper

The development of a [211AT]-astatinated endoradiotherapeutic drug: part IV--late radiation effects

International Journal of Radiation Oncology, Biology, Physics
I Brown, J S Mitchell

Abstract

6-[211At]-astato-MNDP is a high-LET endoradiotherapeutic drug that selectively targets to an oncogenically associated alkaline phosphatase isoenzyme expressed by certain tumors. A detailed histopathological study of the late tissue effects of its endogenous alpha-particle emissions has been carried out in a murine tumor model. Thyroid-blocked male C57BI/10 mice bearing a s.c. transplanted rectal adenocarcinoma were treated with a single i.p. injection of 10-750 kBq 6-[211At]-astato-MNDP. Cured mice (131) were studied. Detailed autopsies and histological examinations were performed on all mice. The study was concluded after 756 days. Lymphoma, plasmacytoma, and intercurrent infections secondary to chronic pulmonary fibrosis were the most commonly found late manifestations of alpha-radiation exposure. Low grade B-cell non-Hodgkin's lymphoma occurred in 19 (24.7%) of 77 mice, 13-17 months after receiving 3.5-185 kBq 6-[211At]-astato-MNDP. The incidence of lymphoma alone and its latency was similar to that of the control population (23.3%). Treatment doses exceeding 200 kBq 6-[211At]-astato-MNDP, were associated with the development of soft tissue plasmacytoma in 7 (13%) of 54 mice, after 17-22 months. Generalized debilitation and ...Continue Reading

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Citations

Sep 16, 1999·International Journal of Radiation Oncology, Biology, Physics·R E McLendonM R Zalutsky
Oct 20, 2009·European Journal of Pharmacology·Frederic ZollerWalter Mier
Jan 19, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·George SgourosPat B Zanzonico

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