PMID: 9438800Jan 23, 1998Paper

The development of a conditioned place preference to morphine: effects of lesions of various CNS sites

Behavioral Neuroscience
M C Olmstead, K B Franklin

Abstract

This study examined the neural substrates underlying the development of a conditioned place preference (CPP) to morphine (2 mg/kg x 3 pairings) by testing whether lesions of 7 different neural sites block a morphine-induced CPP. Lesions of the pedunculopontine tegmental nucleus (PPTg), the periaqueductal gray (PAG), or the fornix reduced the preference for a morphine-paired compartment. When they were retested following morphine administration, fornix- or PAG-lesioned animals exhibited a CPP indicating that lesions did not block morphine-induced reward or the ability to associate this effect with salient environmental cues. PPTg-lesioned animals did not express a CPP during state-dependent testing, suggesting that the lesions may attenuate the rewarding effect of the drug. Lesions of the mesolimbic dopamine system, the ventral pallidum, the lateral nucleus of the amygdala, or the caudate putamen had no effect on a morphine-induced CPP.

Citations

Mar 30, 2004·Brain Research·Mohammad-Reza ZarrindastMajid Jafari-Sabet
May 24, 2005·Pharmacology, Biochemistry, and Behavior·David A WhiteStephen G Holtzman
Aug 7, 2002·European Journal of Pharmacology·Manizheh KaramiHedayat Sahraei
Aug 9, 2002·European Journal of Pharmacology·Azam GholamiMohammad-Reza Zarrindast
Oct 24, 2002·European Journal of Pharmacology·Mohammad Reza ZarrindastHedayat Sahraei
Oct 12, 2002·Pharmacology, Biochemistry, and Behavior·Ameneh RezayofAli-Haeri-Rohani Haeri-Rohani
Jun 7, 2000·Behavioural Brain Research·E A AntoniadisR J McDonald
Sep 21, 2000·Behavioural Brain Research·E A AntoniadisR J McDonald
Jan 8, 1999·Peptides·G A OlsonA J Kastin
Oct 6, 2011·Nature Reviews. Neuroscience·Aldo BadianiYavin Shaham
Feb 20, 2014·Indian Journal of Pharmacology·Manizheh KaramiHedayat Sahraei

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