The development of a glucose clamp.

Metabolism: Clinical and Experimental
K H NorwichG Hetenyi

Abstract

A reliable control system was developed for clamping (i.e., holding at a steady level) the concentration of blood glucose in the hyperglycemic region of a normal nonanesthetized dog. The system is based upon, and hence largely validates, a mathematical model of the canine glucoregulatory mechanism which was assembled from the results of experiments in which radioisotopes were used. The operation of the clamp, however, does not require the use of radioisotopes. The glucose clamp is a tool which may be applicable clinically in the measurement of glucose turnover and in the laboratory in the study of the effects of glucose turnover of variable insulin with constant glucose levels.

References

Jul 1, 1975·Medical & Biological Engineering·S ZelinG Hetenyi
Nov 1, 1972·Medical & Biological Engineering·B PagurekS Mahmoud

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Citations

Mar 1, 1977·Annals of Biomedical Engineering·G HetenyiK H Norwich
Jul 1, 1986·Medical & Biological Engineering & Computing·S M FurlerE W Kraegen
Mar 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·D R MatthewsD B Dunger
Aug 1, 1995·Scandinavian Journal of Clinical and Laboratory Investigation·B M JensenH Orskov
Feb 1, 1994·IEEE Transactions on Bio-medical Engineering·B Candas, J Radziuk
Jan 1, 1986·Diabetic Medicine : a Journal of the British Diabetic Association·R E Ferner, K G Alberti
May 22, 2003·Metabolism: Clinical and Experimental·Edwige BailhacheKhadija Ouguerram

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