The development of a novel intraperitoneal tumor-seeding prophylactic

American Journal of Surgery
J S DemetrickW L Hunter

Abstract

Peritoneal tumor dissemination and implantation is a complication of both open and laparoscopic oncologic surgery. This study evaluates the efficacy of paclitaxel-loaded poly(L-lactic acid) microspheres as prophylaxis against intraabdominal tumor seeding. 2 x 10(6) 9L glioblastoma cells were introduced into the abdominal cavity of Wistar rats. Fifteen minutes later, the peritoneal cavity was washed with the experimental solutions, and 2 weeks later the presence of tumor implantation was determined. After defining the optimum dose of paclitaxel PLA microspheres in a dose-ranging study, the microsphere formulation was then compared with conventional paclitaxel in four experimental groups (n = 5) as follows: 100 mg of 30% paclitaxel-loaded microspheres; 100 mg PLA microspheres; paclitaxel 4.1 mg; and controls receiving no intraabdominal therapy. Although carcinomatosis developed in all control animals, none in the paclitaxel-loaded microsphere group had biopsy proven cancer. The conventional paclitaxel group (3) showed significant toxicity; only 1 animal survived and had positive histology. In this animal model of peritoneal carcinomatosis, the paclitaxel-loaded microsphere formulation was more effective than conventional paclitax...Continue Reading

References

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Nov 1, 1995·Diseases of the Colon and Rectum·D B JonesJ W Fleshman

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Citations

Dec 24, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·C P LuftensteinerH Viernstein
Jun 17, 1999·International Journal of Pharmaceutics·C P LuftensteinerH Viernstein
Sep 25, 2007·Biomaterials·Heather M PowellJohn J Lannutti
Jul 16, 2008·International Journal of Pharmaceutics·Christian Wischke, Steven P Schwendeman
Feb 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hunter H ChenXiaoming Yang

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