Abstract
The determination that a chemical poses a reproductive risk to man typically relies upon fertility studies using rodents. However, fertility in rodents is often difficult to disrupt and more sensitive indicators of reproductive function should be included in the risk assessment process. The present discussion compares the sensitivity of fertility to other endpoints following exposure to known reproductive toxicants. In our studies rats were dosed from weaning through puberty , gestation, and lactation. The reproductive function of the male, the female, and the offspring was assessed. The effects of methoxychlor, carbendazim (MBC), dibutyl phthalate (DBP), and lindane are discussed and compared to fertility. For each compound a ratio (SR = sensitivity ratio) of the lowest effect level (LEL) for infertility or reduced fecundity to the LEL for the most sensitive physiologic endpoint was calculated. The SR should be large when a compound produces effects over a wide range of doses, but should equal unity when the dose-response curve is very steep. For methoxychlor, which blocked implantation, pubertal landmarks and estrous cyclicity provided rapid and sensitive indicators of the subsequent reproductive failure. The SR = 8 (100/12) ...Continue Reading
References
Mar 1, 1979·Journal of Reproduction and Fertility·R M Sharpe
Sep 1, 1977·Biology of Reproduction·C C KorenbrotR I Weiner
Mar 1, 1986·Bulletin of Environmental Contamination and Toxicology·R E LinderW K McElroy
Jan 1, 1984·Teratogenesis, Carcinogenesis, and Mutagenesis·J W Overstreet
May 1, 1983·Archives of Toxicology·S L CassidyT Jenkins
Citations
Oct 14, 2008·Genes & Nutrition·N M SaarinenO Zierau
Jul 17, 1989·Toxicology·J M GoldmanW K McElroy
May 1, 1994·Reproductive Toxicology·J A HoytD E Seyler
Sep 1, 1999·Chemosphere·R J Kavlock
May 22, 2003·Regulatory Toxicology and Pharmacology : RTP·Inge MangelsdorfBruno Orthen
Jun 29, 2002·Molecular and Cellular Endocrinology·Andrea C Gore
Aug 16, 2003·Toxicology Letters·Luis F Oropeza-HernándezArnulfo Albores
Feb 18, 1999·Toxicology Letters·L E Gray
Sep 25, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Stefan O Mueller
Jun 1, 1995·Journal of Toxicology and Environmental Health·E BermanR C MacPhail
Jun 1, 1995·Journal of Toxicology and Environmental Health·R C MacPhailM Schlicht
Sep 30, 2004·ILAR Journal·L E GrayP M D Foster
Feb 19, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Andrew K HotchkissL Earl Gray
Sep 21, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Edward DereRobert E Chapin
Aug 17, 2010·Indian Journal of Pharmacology·Laxminarayana BairyYeshwanth Rao
May 7, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Johnathan R FurrLeon E Gray
Dec 8, 2004·American Journal of Epidemiology·S L FarrD P Sandler
Sep 29, 2011·Journal of Neuroendocrinology·C A FryeG C Panzica
Apr 23, 2016·Reproductive Toxicology·Troy A RoepkeMehmet Uzumcu
Apr 20, 2010·Reproductive Toxicology·Patricia PazosSusanne Bremer
May 16, 2003·Biology of Reproduction·Dana K Tarka-LeedsGary R Klinefelter
Sep 20, 2000·Biology of Reproduction·L P Walsh, D M Stocco
Apr 12, 2000·Critical Reviews in Toxicology·J M GoldmanR J Kavlock
Apr 3, 1999·Toxicology and Industrial Health·C WolfL E Gray
Feb 24, 2006·American Journal of Epidemiology·Sherry L FarrGlinda S Cooper
Feb 15, 2008·Pediatrics·Mari S GolubJorma Toppari