The development of cervical cancer and its precursors: what is the role of human papillomavirus infection?

Current Opinion in Obstetrics & Gynecology
J Thomas Cox

Abstract

Human papillomavirus (HPV) is a significant health care burden in the United States. The majority of sexually active men and women will be infected with HPV at some point in their lives and are subject to developing human papillomavirus-associated disease. Current estimates suggest that 20 million Americans are currently infected, and more than 5 million new infections occur each year. The prevalence of human papillomavirus is highest in populations in their late teens and early twenties, with nearly half of all new human papillomavirus infections occurring within 3 years of first intercourse. HPV is the necessary cause of genital warts, cervical intraepithelial neoplasia, and invasive cervical cancer. As such, human papillomavirus is responsible for significant medical morbidity and health care costs. Screening with cervical cytology has significantly reduced mortality rates; however, approximately 3900 women will die in 2005 from cervical cancer in the United States. Human papillomavirus DNA testing has shown promise in identifying high-grade abnormalities as an adjunct to traditional cytology, and should be used according to guidelines established by the American Cancer Society and the American College of Obstetricians and G...Continue Reading

References

Jul 17, 1991·Journal of the National Cancer Institute·C LeyM M Manos
Jan 1, 1991·American Journal of Obstetrics and Gynecology·R MatorrasF J Rodriguez-Escudero
Jan 1, 1990·American Journal of Obstetrics and Gynecology·C BergeronR Richart
Jan 1, 1988·Epidemiologic Reviews·L A KoutskyK K Holmes
Sep 20, 1995·Journal of the National Cancer Institute·G Y HoS Romney
Feb 1, 1994·The Journal of Infectious Diseases·A HildesheimM E Sherman
Mar 15, 1994·International Journal of Cancer. Journal International Du Cancer·G Y HoR S Klein
Sep 1, 1993·Sexually Transmitted Diseases·H M BauerM M Manos
Apr 1, 1993·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·A G Ostör
Mar 1, 1997·Sexually Transmitted Diseases·C D LytleW H Cyr
May 1, 1997·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·R HerreroL A Brinton
May 5, 1997·The American Journal of Medicine·L Koutsky
Oct 23, 1997·The Journal of Infectious Diseases·R B RodenJ T Schiller
Feb 12, 1998·The New England Journal of Medicine·G Y HoR D Burk
Mar 21, 1998·American Journal of Obstetrics and Gynecology·D H WattsD A Galloway
May 29, 1998·Journal of Clinical Pathology·M J ArendsM Wells
Oct 9, 1998·Obstetrics and Gynecology·J MelnikowL P Howell
Feb 26, 1999·Journal of the National Cancer Institute·P HolowatyT To
Aug 19, 1999·The Journal of Pathology·J M WalboomersN Muñoz
Mar 27, 2001·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·F CarneiroM Sobrinho-Simões
May 9, 2001·The Journal of Infectious Diseases·C L PeytonC M Wheeler
Jun 30, 2001·JAMA : the Journal of the American Medical Association·A B MoscickiJ Palefsky
Jul 14, 2001·Journal of the European Academy of Dermatology and Venereology : JEADV·W Aberer, B Kränke
Jan 5, 2002·JAMA : the Journal of the American Medical Association·N F SchlechtE L Franco
Feb 15, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·C MartinelliI Ruffino
Mar 29, 2002·Journal of Clinical Pathology·F X BoschK V Shah
Apr 12, 2002·Lancet·Victor MorenoUNKNOWN International Agency for Research on Cancer. Multicentric Cervical Cancer Study Group
Apr 12, 2002·Lancet·Nubia MuñozUNKNOWN International Agency for Research on Cancer. Multicentric Cervical Cancer Study Group
Apr 12, 2002·The New England Journal of Medicine·Xavier CastellsaguéUNKNOWN International Agency for Research on Cancer Multicenter Cervical Cancer Study Group
Apr 23, 2002·JAMA : the Journal of the American Medical Association·Diane SolomonUNKNOWN Bethesda 2001 Workshop
Apr 23, 2002·JAMA : the Journal of the American Medical Association·Thomas C WrightUNKNOWN ASCCP-Sponsored Consensus Conference

❮ Previous
Next ❯

Citations

Aug 21, 2013·Journal of Biomedical Science·Mariel Garcia-ChagollanSusana del Toro-Arreola
Oct 11, 2007·PloS One·Tom J LittleTed Hupp
May 24, 2011·Journal of Pediatric and Adolescent Gynecology·Maria D MerzoukMichael Vernon
Dec 28, 2010·Women's Health Issues : Official Publication of the Jacobs Institute of Women's Health·Ilona JuraskovaKirsten Jo McCaffery
Jul 19, 2018·Ciência & saúde coletiva·Valdir Monteiro PintoEliana Battaggia Gutierrez
Nov 30, 2018·Diagnostic Cytopathology·Hongxia SunVijayalakshmi Padmanabhan
Dec 31, 2009·Journal of Lower Genital Tract Disease·Henry J HenkTheodore Darkow
Apr 25, 2014·Pharmacognosy Research·Krishna Mohan Surapaneni, Mallika Jainu
Apr 10, 2007·JAAPA : Official Journal of the American Academy of Physician Assistants·Debi Gerbert, UNKNOWN AAPA Clinical and Scientific Affairs Council
Jun 22, 2010·Revista Da Sociedade Brasileira De Medicina Tropical·Ludmila Gonçalves EntiauspeAna Maria Barral de Martinez
May 31, 2018·International Journal of Environmental Research and Public Health·Edmond Pui Hang ChoiDaniel Yee Tak Fong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved