The development of colitogenic CD4(+) T cells is regulated by IL-7 in collaboration with NK cell function in a murine model of colitis

The Journal of Immunology : Official Journal of the American Association of Immunologists
Osamu YamajiMamoru Watanabe

Abstract

We previously reported that IL-7(-/-)RAG(-/-) mice receiving naive T cells failed to induce colitis. Such abrogation of colitis may be associated with not only incomplete T cell maintenance due to the lack of IL-7, but also with the induction of colitogenic CD4(+) T cell apoptosis at an early stage of colitis development. Moreover, NK cells may be associated with the suppression of pathogenic T cells in vivo, and they may induce apoptosis of CD4(+) T cells. To further investigate these roles of NK cells, RAG(-/-) and IL-7(-/-)RAG(-/-) mice that had received naive T cells were depleted of NK cells using anti-asialo GM1 and anti-NK1.1 Abs. NK cell depletion at an early stage, but not at a later stage during colitogenic effector memory T cell (T(EM)) development, resulted in exacerbated colitis in recipient mice even in the absence of IL-7. Increased CD44(+)CD62L(-) T(EM) and unique CD44(-)CD62L(-) T cell subsets were observed in the T cell-reconstituted RAG(-/-) recipients when NK cells were depleted, although Fas, DR5, and IL-7R expressions in this subset differed from those in the CD44(+)CD62L(-) T(EM) subset. NK cell characteristics were the same in the presence or absence of IL-7 in vitro and in vivo. These results suggest th...Continue Reading

References

Feb 24, 1989·Journal of Immunological Methods·S E Slezak, P K Horan
May 1, 1985·Journal of Leukocyte Biology·R H WiltroutH T Holden
Dec 31, 1997·The Journal of Experimental Medicine·B ZhangT Tabira
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Motomi YamazakiMamoru Watanabe
Dec 10, 2003·The Journal of Experimental Medicine·Robyn M KondrackLinda M Bradley
Dec 31, 2003·Trends in Immunology·Megan A CooperMichael A Caligiuri
Jul 2, 2004·Brain : a Journal of Neurology·Kazuya TakahashiTakashi Yamamura
Nov 20, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Eriko OkadaMamoru Watanabe
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian A J VosshenrichJames P Di Santo
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·William C KieperCharles D Surh
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Booki MinWilliam E Paul
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Terry J Fry, Crystal L Mackall
Jun 4, 2005·Blood·Thierry WalzerEric Vivier
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshihiro Hayakawa, Mark J Smyth
Mar 23, 2006·Annual Review of Immunology·James P Di Santo
Jul 11, 2006·Immunological Reviews·Charles D SurhJonathan Sprent
Oct 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Toshimasa AranamiTakashi Yamamura
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Teruji TotsukaMamoru Watanabe
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shin MakitaMamoru Watanabe
Dec 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takayuki TomitaMamoru Watanabe
Apr 22, 2008·Nature Immunology·Eric VivierSophie Ugolini
Nov 27, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dmitry V OstaninMatthew B Grisham
Jan 31, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michio OnizawaMamoru Watanabe
Jul 16, 2009·Molecular Medicine·Anna LünemannChristian Münz
Jul 29, 2009·European Journal of Immunology·Takayuki TomitaMamoru Watanabe
Jan 19, 2010·Immunity·Bas J G BaatenLinda M Bradley

❮ Previous
Next ❯

Citations

Apr 14, 2016·Nutrients·Teresa VezzaJulio Galvez
Jan 27, 2018·The Journal of Cell Biology·Jaehak OhJeoung-Sook Shin
Nov 12, 2014·World Journal of Gastroenterology : WJG·Feng-Yan YuXue-Bao Zheng
Feb 24, 2019·Nature Communications·Yu Hui KangScott B Snapper
Apr 5, 2021·Cellular and Molecular Gastroenterology and Hepatology·Roman KosoyMayte Suárez-Fariñas
Jun 21, 2021·Journal of Gastroenterology·Takehito AsakawaMamoru Watanabe

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.