The Development of Compartmentation of cAMP Signaling in Cardiomyocytes: The Role of T-Tubules and Caveolae Microdomains

Journal of Cardiovascular Development and Disease
Navneet K BhogalJulia Gorelik

Abstract

3′-5′-cyclic adenosine monophosphate (cAMP) is a signaling messenger produced in response to the stimulation of cellular receptors, and has a myriad of functional applications depending on the cell type. In the heart, cAMP is responsible for regulating the contraction rate and force; however, cAMP is also involved in multiple other functions. Compartmentation of cAMP production may explain the specificity of signaling following a stimulus. In particular, transverse tubules (T-tubules) and caveolae have been found to be critical structural components for the spatial confinement of cAMP in cardiomyocytes, as exemplified by beta-adrenergic receptor (β-ARs) signaling. Pathological alterations in cardiomyocyte microdomain architecture led to a disruption in compartmentation of the cAMP signal. In this review, we discuss the difference between atrial and ventricular cardiomyocytes in respect to microdomain organization, and the pathological changes of atrial and ventricular cAMP signaling in response to myocyte dedifferentiation. In addition, we review the role of localized phosphodiesterase (PDE) activity in constraining the cAMP signal. Finally, we discuss microdomain biogenesis and maturation of cAMP signaling wit...Continue Reading

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Citations

Feb 18, 2020·Biochemical Society Transactions·Tamara Pallien, Enno Klussmann
Jan 11, 2020·Frontiers in Physiology·Sarah Helena VermijJan Pavel Kucera
Aug 11, 2020·Pigment Cell & Melanoma Research·Jakyung Bang, Jonathan H Zippin
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Maria DudãuMihail E Hinescu
Dec 17, 2020·Journal of Molecular and Cellular Cardiology·Maria T MoraBeatriz Trenor

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Methods Mentioned

BETA
confocal microscopy

Software Mentioned

SICM

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