PMID: 2287026Dec 1, 1990Paper

The development of drug-metabolizing enzymes in female sheep livers

Journal of Veterinary Pharmacology and Therapeutics
M KaddouriP Galtier

Abstract

The purpose of this investigation was to determine age-related changes of some hepatic drug-metabolizing activities in Lacaune ewes in the foetal, neonatal (1 and 4 weeks), growing (7 months), pregnant (11 months) and adult (6 years) stages. Although microsomal cytochrome P-450 was not detected in 3-month-old foetuses, it increased regularly from 1-week- to 11-month-old animals. Among mixed-function oxidases, the development of aminopyrine and ethylmorphine N-demethylases, benzo(alpha)pyrene hydroxylase and ethoxycoumarin O-deethylase were correlated to that of total cytochrome P-450. Due to their presence in foetal liver or their more rapid evolution, cytochrome b5, NADPH cytochrome c reductase, aniline hydroxylase, benzphetamine N-demethylase and erythromycin N-demethylase did not parallel the ontogenesis of cytochrome P-450. Hepatic transferases showed different developmental patterns from mono-oxygenases, so UDP glucuronyltransferase was detected in the foetus, reached maximum activity in all young ages up to the pregnant stage and subsequently fell in adult ewes. Concerning glutathione S-transferase accepting 1-chloro-2,4-dinitrobenzene as substrate, similar values were obtained in the foetus and all young animals, whereas...Continue Reading

References

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Citations

Jan 1, 1990·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M KaddouriP Galtier
Jun 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·M KaddouriP Galtier
Jul 12, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C EeckhoutteM Dacasto
Mar 15, 2011·Journal of Veterinary Pharmacology and Therapeutics·T K FosseB Ranheim
Sep 18, 2014·Journal of Veterinary Pharmacology and Therapeutics·S X Hu

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