PMID: 2287026Dec 1, 1990Paper

The development of drug-metabolizing enzymes in female sheep livers

Journal of Veterinary Pharmacology and Therapeutics
M KaddouriP Galtier


The purpose of this investigation was to determine age-related changes of some hepatic drug-metabolizing activities in Lacaune ewes in the foetal, neonatal (1 and 4 weeks), growing (7 months), pregnant (11 months) and adult (6 years) stages. Although microsomal cytochrome P-450 was not detected in 3-month-old foetuses, it increased regularly from 1-week- to 11-month-old animals. Among mixed-function oxidases, the development of aminopyrine and ethylmorphine N-demethylases, benzo(alpha)pyrene hydroxylase and ethoxycoumarin O-deethylase were correlated to that of total cytochrome P-450. Due to their presence in foetal liver or their more rapid evolution, cytochrome b5, NADPH cytochrome c reductase, aniline hydroxylase, benzphetamine N-demethylase and erythromycin N-demethylase did not parallel the ontogenesis of cytochrome P-450. Hepatic transferases showed different developmental patterns from mono-oxygenases, so UDP glucuronyltransferase was detected in the foetus, reached maximum activity in all young ages up to the pregnant stage and subsequently fell in adult ewes. Concerning glutathione S-transferase accepting 1-chloro-2,4-dinitrobenzene as substrate, similar values were obtained in the foetus and all young animals, whereas...Continue Reading


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Jan 1, 1990·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M KaddouriP Galtier
Jun 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·M KaddouriP Galtier
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Mar 15, 2011·Journal of Veterinary Pharmacology and Therapeutics·T K FosseB Ranheim
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