PMID: 8972762Nov 1, 1996Paper

The development of focal segmental glomerulosclerosis in masugi nephritis is based on progressive podocyte damage

Virchows Archiv : an International Journal of Pathology
I ShiratoWilhelm Kriz

Abstract

We analysed the sequence of structural changes leading to focal segmental glomerulosclerosis (FSGS) in chronic Masugi nephritis. The protocol resulted in an immediate onset of the disease and the development of segmental sclerosis in a considerable proportion of glomeruli within 28 days of serum injection. Throughout the study, the degree of structural damage was significantly correlated with protein excretion. Even 1 day after injection of the serum, the whole spectrum of early lesions was encountered involving all three cell types. Endothelial detachments, mesangiolysis and podocyte foot process effacement were most prominent. There was focal persistence of capillary microthrombosis but, generally, mesangial and endothelial injuries recovered. The development of podocyte lesions was different: on one hand recovery was seen leading to the re-establishment of an interdigitating foot process pattern, and on the other persistent podocyte detachments from peripheral capillaries allowed the attachment of parietal epithelial cells to "naked" portions of the glomerular basement membrane (GBM), and thus to the formation of a tuft adhesion to Bowman's capsule. Progressive podocyte degeneration at the flanks of an adhesion permitted exp...Continue Reading

Citations

May 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Shu-ichi ItoMasataka Honda
Aug 15, 1998·Pathology International·H Shimojo
Oct 16, 2004·Kidney International. Supplement·Kambiz Zandi-NejadBarry M Brenner
Jan 28, 2005·Kidney International·Wilhelm Kriz, Michel LeHir
Jul 2, 2011·Journal of the American Society of Nephrology : JASN·Taiji MatsusakaIekuni Ichikawa
Sep 12, 1998·Kidney International·W KrizK V Lemley
Jun 1, 1996·Kidney International·W KrizI Shirato
May 29, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marcello Camici
May 12, 2016·Kidney International·Michio Nagata
Sep 11, 2012·Seminars in Nephrology·Nicole Endlich, Karlhans Endlich
Jun 15, 2010·The International Journal of Biochemistry & Cell Biology·Huifang Cheng, Raymond C Harris
Nov 25, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sabine LehTerje Forslund
Feb 27, 2016·F1000Research·Jochen Reiser, Mehmet M Altintas
Jan 19, 2007·American Journal of Physiology. Renal Physiology·William A Cupples, Branko Braam
May 26, 2005·American Journal of Physiology. Renal Physiology·Jenny ZiembickiChunfa Huang
Sep 24, 1999·Current Opinion in Nephrology and Hypertension·W Kriz, K V Lemley
Feb 11, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kayo HayashiPaul E Klotman

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