PMID: 44249Jan 1, 1979

The development of inducibility for glutamine synthetase in embryonic neural retina: inhibition by BrdU

Differentiation; Research in Biological Diversity
M Moscona, A A Moscona

Abstract

The hydrocortisone-mediated induction of glutamine synthetase (GS) in the neural retina of the chick embryo is a characteristic and unique feature of differentiation of this tissue. The induction involves genomic activity elicited by the inducer resulting in synthesis and accumulation of the enzyme. We describe correlations between the growth of embryonic retina tissue in vivo and in vitro and the development of its inducibility for GS, and demonstrate that this development proceeds through two phases: competence-acquisition phase (before the 7th day of development), and maturation phase. BrdU applied for 24 h to retinas of 5-day embryos irreversibly suppresses the development of induction-competence. However, BrdU does not affect the progressive maturation of inducibility when applied to retinas that already are fully induction-competent (8 days and older). The short treatment with BrdU of 5-day retinas also causes defective histogenesis resulting in drastic malformation of the tissue. The nature of the processes involved in competence-acquisition and in the maturation of inducibility for GS are examined. Possible mechanisms by which BrdU prevents the development of induction-competence for GS in the early embryonic retina and...Continue Reading

References

Mar 1, 1991·The American Journal of Anatomy·R M ShahE J Feeley
Apr 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L VardimonL E Fox
Jan 1, 1981·Cell Differentiation·A A Moscona, L Degenstein
Sep 1, 1985·Cell Differentiation·I OphirY Ben-Shaul
Jun 1, 1985·Cell Differentiation·A D Saad, A A Moscona
May 1, 1984·Brain Research·C A LandaH J Maccioni
Feb 1, 1994·Brain Research. Molecular Brain Research·R GrossmanL Vardimon
Jan 1, 1985·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C A Landa, A A Moscona
Dec 1, 1988·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·A A MosconaL Degenstein
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P Linser, A A Moscona
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A A MosconaB M Soh
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L VardimonA A Moscona
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·H ZhangA P Young
Jan 1, 1979·Differentiation; Research in Biological Diversity·P L Mayerson, A A Moscona
Aug 24, 1999·The European Journal of Neuroscience·B Hellmann, O Güntürkün

Citations

Sep 1, 1975·Archives of Biochemistry and Biophysics·D E Koehler, A A Moscona
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·C M StromA Dorfman
Jan 1, 1979·Differentiation; Research in Biological Diversity·P L Mayerson, A A Moscona
Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·C M Strom, A Dorfman
Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·C M Strom, A Dorfman
Jun 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·P K Sarkar, A A Moscona
May 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·D Levitt, A Dorfman
Jun 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·R H Stellwagen, G M Tomkins
Sep 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·P K Sarkar, A A Moscona
Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·S A Schwartz, W H Kirsten
Jan 1, 1970·Zeitschrift für Zellforschung und mikroskopische Anatomie·J B Sheffield, D A Fischman
Sep 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·A A MosconaN Saenz

Related Concepts

Depression, Chemical
Thymidine
Glutamine Deficiency, Congenital
Organ Culture Techniques
GLUL
Glutamate-Ammonia Ligase
Cell Differentiation Process
Tritium
Retina
Chick Embryo

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