The development of morphine tolerance and dependence in rats with chronic pain

Brain Research
W YuZ Wiesenfeld-Hallin

Abstract

The development of tolerance and dependence to morphine injected onto the spinal cord was examined in a model of chronic pain following spinal cord injury in rats. Intrathecal morphine completely relieved the marked pain-like response of these rats to innocuous mechanical stimuli. The analgesic effect of morphine injected twice daily was, however, diminished within a few days. Tolerance to the antinociceptive effect of morphine assessed with the tail flick test also developed similarly in rats with chronic pain and in normal controls. Both groups exhibited similar signs of naloxone-precipitated withdrawal after 3 weeks of morphine treatment. The results suggest that the presence of chronic pain-like behavior did not prevent the development of morphine tolerance and dependence, even when morphine was used to treat the chronic pain itself.

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Citations

Dec 23, 2004·Journal of Molecular Histology·Christopher J BrinkerhoffJennifer J Linderman
Dec 5, 2003·Trends in Pharmacological Sciences·Xiao-Jun XuZsuzsanna Wiesenfeld-Hallin
Jan 8, 1999·Peptides·G A OlsonA J Kastin
Jan 5, 2012·Journal of Neurotrauma·Sarah A WollerMichelle A Hook
Jun 25, 2008·The Clinical Journal of Pain·Jane C Ballantyne, Naomi S Shin
Feb 24, 2016·Future Medicinal Chemistry·Frédéric Bihel
Jun 10, 2006·Biochemical and Biophysical Research Communications·Zhifang DongLin Xu
Feb 1, 2011·Pharmacology, Biochemistry, and Behavior·Megan L UhelskiPerry N Fuchs
May 8, 2007·Pain·Jane C Ballantyne, Steven K LaForge
Oct 23, 2003·Anesthesia and Analgesia·Thomas MeuserPamela Pierce Palmer
Mar 2, 2006·Anesthesiology·Martin S Angst, J David Clark
Mar 4, 2005·The Journal of Pharmacology and Experimental Therapeutics·V L TawfikJ A DeLeo
Jul 21, 2010·Experimental Neurology·Megan Ryan DetloffD Michele Basso

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