The development of neural visinin-like Ca(2+)-binding protein 2 immunoreactivity in the rat neocortex and hippocampus

Neuroscience Research
S SaitohK Takamatsu

Abstract

Neural visinin-like Ca(2+)-binding protein 2 (NVP2) immunoreactivity in the rat neocortex and hippocampus was barely detectable by immunoblot analysis on postnatal day 1 (P1), but increased during postnatal weeks 2-3, reaching a plateau on P28. Immunohistochemical analysis revealed moderate immunoreactivity firstly on P7 in some subsets of the hippocampal interneurons and in the hippocampal pyramidal cells and dentate granule cells. Immunoreactivity of the interneurons decreased during postnatal weeks 2-3 and disappeared by P28. In contrast, immunoreactivity of the cortical and hippocampal pyramidal cells and dentate granule cells abruptly increased during postnatal week 2. The distinctly immunoreactive cells were distributed throughout the neocortex, especially in the cortical plate, and the stratum pyramidale of Ammon's horn and granular layer of the dentate gyrus on P14. Immunoreactivity was homogeneously concentrated in the cell bodies and proximal dendrites at this stage, whereas thereafter immunoreactivity in the neuropil gradually increased, and underwent a relative decrease in the cell bodies. By P28, the higher and granular immunoreactivity in the neuropil covered whole layers of the neocortex, Ammon's horn and the den...Continue Reading

References

Nov 30, 1992·Biochemical and Biophysical Research Communications·M KobayashiT Noguchi
May 15, 1992·Biochemical and Biophysical Research Communications·T KunoC Tanaka
Feb 28, 1992·Biochemical and Biophysical Research Communications·K TakamatsuT Noguchi
May 29, 1992·Biochemical and Biophysical Research Communications·K OkazakiH Hidaka
Jul 15, 1994·Brain Research. Developmental Brain Research·S SaitohT Noguchi
Jul 9, 1993·Neuroscience Letters·S SaitohT Noguchi

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Citations

Oct 26, 1999·The Journal of Biological Chemistry·P M MathisenV K Tuohy
May 15, 1998·Hippocampus·F J Martínez-GuijarroJ R Alonso

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