The development of new clinical instruments in laryngopharyngeal reflux disease: The international project of young otolaryngologists of the International Federation of Oto-rhino-laryngological Societies

European Annals of Otorhinolaryngology, Head and Neck Diseases
J R LechienS Saussez

Abstract

To analyze the epidemiological characteristics of placebo controlled randomized trials (RCTs) that evaluated the effectiveness of medical treatments over placebo in laryngopharyngeal reflux (LPR). PubMed, Cochrane database, and Scopus were assessed for subject headings using the PRISMA recommendations. Placebo RCTs published between 1990 and 2018 describing clinical evolution throughout LPR treatment were extracted and analyzed for evidence-based level, number of patients, inclusion and exclusion criteria, gender, age, symptoms and signs used as therapeutic outcomes, and treatment schemes. The database search identified 15 placebo RCTs with a total of 763 patients. The mean age of patients was 48.59 years and 52.68% of patients were female. Among the 15 placebo RCTs, 9 have demonstrated a partial or total superiority of a medical treatment over placebo. Most of authors based the LPR diagnosis on symptoms and signs without additional examination. Our analysis reveals an important heterogeneity between studies with regard to the diagnosis criteria, treatment schemes and signs and symptoms used as therapeutic outcomes. Many commonly reported signs and symptoms related to LPR were not used as therapeutic outcomes. Half of the autho...Continue Reading

Citations

Feb 13, 2019·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jerome R LechienMichael F Vaezi
Apr 16, 2019·The Laryngoscope·Jérôme R LechienSven Saussez
May 3, 2019·JAMA Otolaryngology-- Head & Neck Surgery·Jérôme R LechienPiero Marco Fisichella
May 26, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Shuifang XiaoJinlong Ren
Jul 2, 2019·The Annals of Otology, Rhinology, and Laryngology·Jerome R LechienPetros D Karkos
Dec 2, 2020·European Annals of Otorhinolaryngology, Head and Neck Diseases·J-R LechienS Saussez

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