The Development of New Small-Molecule Inhibitors Targeting Bacterial Metallo-β-lactamases

Current Topics in Medicinal Chemistry
Ping WangJunbiao Chang

Abstract

Metallo-β-lactamases (MBLs) are a family of Zn(II)-dependent enzymes that can hydrolyze almost all β-lactam antibiotics. Horizontal transfer of the genes encoding MBLs among Gram-negative bacteria pathogens has led to the emergence of extensively drug-resistant pathogens, which now represent a major threat to human health. As there is not to date yet a clinically available MBL inhibitor, the discovery of new MBL inhibitors has great urgency. This review highlights the recent developments in the discovery of small-molecule MBL inhibitors.

Citations

Jul 16, 2020·Archiv der Pharmazie·Feng SongMeng Zhou
Oct 31, 2019·Journal of Medicinal Chemistry·Concepción González-BelloEsther Colchón

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