The Development of Oral Amphotericin B to Treat Systemic Fungal and Parasitic Infections: Has the Myth Been Finally Realized?

Pharmaceutics
Grace CuddihyKishor M Wasan

Abstract

Parenteral amphotericin B has been considered as first-line therapy in the treatment of systemic fungal and parasitic infections, however its use has been associated with a number of limitations including affordability, accessibility, and an array of systemic toxicities. Until very recently, it has been very challenging to develop a bioavailable formulation of amphotericin B due to its physical chemical properties, limited water and lipid solubility, and poor absorption. This perspective reviews several novel oral Amphotericin B formulations under development that are attempting to overcome these limitations.

References

Jan 1, 1970·Annual Review of Pharmacology·S C Kinsky
Jul 18, 2002·Antimicrobial Agents and Chemotherapy·G DelmasD S Perlin
Nov 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Andrew J PhillipsMark Ramsdale
Jul 5, 2008·International Journal of Pharmaceutics·Raquel EspadaJuan J Torrado
Jun 24, 2009·The Journal of Infectious Diseases·Kishor M WasanSheila J Thornton
Jun 16, 2010·Drug Development and Industrial Pharmacy·Sheila J ThorntonEllen K Wasan
Jul 8, 2010·Journal of Global Infectious Diseases·Shyam Sundar, Jaya Chakravarty
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Daniel S PalaciosMartin D Burke
Mar 12, 2011·The Journal of Antimicrobial Chemotherapy·Vijay Kumar PrajapatiShyam Sundar
Aug 9, 2011·Cellular Microbiology·Lynette Beattie, Paul M Kaye
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Kaitlyn C GrayMartin D Burke
Jun 14, 2012·PloS One·Jorge AlvarUNKNOWN WHO Leishmaniasis Control Team
Oct 2, 2012·Frontiers in Microbiology·Ana C Mesa-ArangoOscar Zaragoza
Jan 5, 2013·Journal de mycologie médicale·L Belkherroubi-SariK Boucherit
Apr 30, 2013·International Journal of Biological Macromolecules·Kuldeep SinghVikas Rana
Jun 4, 2013·International Journal of Pharmaceutics·Acarília Eduardo SilvaE Sócrates T Egito
Jul 23, 2013·International Journal of Pharmaceutics·T T H PhamG Barratt
Nov 14, 2013·Cellular and Molecular Life Sciences : CMLS·Dawn M WalkerAbhay R Satoskar
Apr 1, 2014·Nature Chemical Biology·Thomas M AndersonMartin D Burke
Oct 28, 2014·Expert Opinion on Pharmacotherapy·Shyam Sundar, Jaya Chakravarty
Dec 6, 2014·TheScientificWorldJournal·Saurabh BhatiaTanmoy Bera
Jan 7, 2015·Molecular Pharmaceutics·Dolores R SerranoIjeoma F Uchegbu
Aug 12, 2015·Antimicrobial Agents and Chemotherapy·Eddie GraceKris Virga
Dec 30, 2015·Drug Delivery and Translational Research·Manisha B ChaudhariVandana B Patravale
Apr 13, 2017·International Journal of Pharmaceutics·Raquel Fernández-GarcíaDolores R Serrano
Apr 17, 2017·International Journal of Medical Microbiology : IJMM·José P Guirao-AbadJuan-Carlos Argüelles
Jun 27, 2017·F1000Research·Edoardo Torres-GuerreroRoberto Arenas
Sep 28, 2017·Revista Da Sociedade Brasileira De Medicina Tropical·Tália Santana Machado de AssisAna Rabello

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Citations

Oct 20, 2019·Pharmaceutics·Kishor M Wasan, Ildiko Badea
Jan 8, 2020·Pharmaceutics·Célia Faustino, Lídia Pinheiro
Feb 27, 2020·Open Forum Infectious Diseases·Adriana M RauseoAndrej Spec
Aug 18, 2020·International Journal of Biomaterials·Merlis P Alvarez-BerriosDavid Sanchez-Rodriguez
Feb 5, 2021·Chonnam Medical Journal·Eun-Mi Kim, Hwan-Jeong Jeong
Apr 22, 2021·Expert Opinion on Pharmacotherapy·Scott W MuellerKyle C Molina
May 22, 2021·Infectious Disease Clinics of North America·Melissa D Johnson

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Methods Mentioned

BETA
nanoprecipitation

Software Mentioned

AmbiOnp

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