PMID: 2450021Feb 1, 1988Paper

The development of rat alpha 2-macroglobulin. Studies in vivo and in cultured fetal rat hepatocytes

European Journal of Biochemistry
S FletcherG C Yeoh

Abstract

During inflammation and tissue injury, there is an increase in the plasma concentration of several proteins, the acute-phase proteins. The levels of some acute-phase proteins have been reported to increase in pregnant and tumour-bearing animals. Rat alpha 2-macroglobulin is classified as an acute-phase protein. In this study we report the expression of alpha 2-macroglobulin in various tissues during development of the rat embryo by analysis of mRNA. The tissues studied are liver, visceral yolk sac, placental labyrinth, decidua and trophoblast. In addition, the sites of alpha 2-macroglobulin expression are localized by in situ hybridization of cDNA for alpha 2-macroglobulin to mid-sagittal cryosections of rat embryos. The level of mRNA coding for alpha 2-macroglobulin is determined in the liver of rats aged between 12 days gestation and 2 days postnatal. alpha 2-Macroglobulin mRNA is first observed in fetal liver from 12 days of gestation and increases after day 17, reaching a maximum on day 20. At this time the level is greater than that found in the liver of an adult rat suffering from acute inflammation. alpha 2-Macroglobulin mRNA is detectable in the yolk sac, placental labyrinth, trophoblast tissue and decidua. In the decid...Continue Reading

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Citations

Jun 1, 1996·The International Journal of Biochemistry & Cell Biology·C M HilliardG C Yeoh
Feb 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S K MagnusonJ P Gorski
May 1, 1992·Differentiation; Research in Biological Diversity·M GlibetícL Sevaljević
Jan 1, 1994·Critical Reviews in Biochemistry and Molecular Biology·S S Twining
Jan 1, 1989·Annals of the New York Academy of Sciences·G SchreiberJ Milland
Mar 14, 1995·Biochimica Et Biophysica Acta·T ThomasP Rogers

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