PMID: 3755620Sep 4, 1986Paper

The development of surfactant synthesis in fetal rabbit lung organ culture exhibits a sex dimorphism

Biochimica Et Biophysica Acta
H C Nielsen

Abstract

Sex differences in amniotic fluid and lung lavage surfactant have been found. Although these studies suggest that augmented fetal surfactant synthesis occurs earlier in the female fetus, there is little direct evidence for a sex difference in fetal surfactant synthesis. We studied the synthesis of surfactant by evaluating the appearance of labelled phospholipids in lamellar bodies recovered from sex-specific organ culture of fetal rabbit lungs. Furthermore, we studied the ability of dexamethasone to stimulate surfactant synthesis in male and female fetal lungs. Organ culture was begun on day 21 of gestation. After 5 days the incorporation of [1,3-14C]glycerol into phosphatidylcholine (PC), disaturated phosphatidylcholine, phosphatidylinositol (PI), and phosphatidylglycerol was studied. Female lungs in organ culture synthesized more disaturated PC per milligram protein than male lungs. In the presence of dexamethasone (10(-8) M) and dihydrotestosterone (10(-8) M) an increased synthesis was noted in the female cultures of PC (270%), disaturated PC (234%), PI (281%), and phosphatidylglycerol (754%). No significant increase in the synthesis of PC or disaturated PC was observed in the male cultures. However in the male cultures smal...Continue Reading

References

Aug 1, 1985·The Journal of Allergy and Clinical Immunology·A WannerH Gazeroglu
Sep 1, 1981·Pediatric Research·H C Nielsen, J S Torday
Mar 1, 1982·The Journal of Clinical Investigation·H C NielsenJ S Torday
Jul 15, 1981·Developmental Biology·J M SnyderJ M Johnston
Dec 1, 1981·Archives of Biochemistry and Biophysics·K J LongmuirJ M Johnston

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Citations

Apr 5, 2016·Biology of Sex Differences·Wafae BouhaddiouiYves Tremblay
Dec 10, 1999·Pediatric Research·D M McCoyR K Mallampalli
Oct 6, 2000·APMIS. Supplementum·U L Holmskov
Mar 6, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Horst FischerPhilip L Ballard
Jan 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K R Khubchandani, J M Snyder
Sep 28, 2006·The Journal of Clinical Endocrinology and Metabolism·Kang SunLeslie Myatt
Dec 15, 1992·Biochimica Et Biophysica Acta·H C NielsenC A Doyle
Jan 13, 1992·Biochimica Et Biophysica Acta·J M Klein, H C Nielsen

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