PMID: 1201482Oct 1, 1975Paper

The development of sympathetic innervation and the functional state of the cardiovascular system in newborn dogs

Canadian Journal of Physiology and Pharmacology
P GauthierJ de Champlain

Abstract

The present study in dogs indicates that the peripheral sympathetic fibers develop mostly after birth and reach a full maturity at about 2 months of life. The norepinephrine content of the heart, spleen, intestine, salivary glands, and adrenal glands increased from birth to 56 days of age. In contrast, the content of the stellate ganglia decreased during this period. In most of the organs studied, the uptake of [3H] norepinephrine developed in parallel with the norepinephrine content, except in the right atrium and salivary glands where it was fully developed soon after birth. During development, the systemic blood pressure increased from 40 to 100 mm Hg. Bilateral adrenal vessel clamping failed to induce a fall in blood pressure in growing dogs which indicates that the adrenal medulla or the baroreceptors did not fully compensate for the lack of peripheral sympathetic fibers and for the lower blood pressure in newborn animals. Although cardiac norepinephrine content was still very low in 10-day-old animals, cardiovascular responses to direct and reflex sympathetic stimulation were similar to those observed in 56-day-old animals. These results indicate that the sympathetic nervous system becomes functional before the fibers rea...Continue Reading

Citations

Nov 17, 1998·The Journal of Small Animal Practice·N S Moïse
Feb 9, 2005·The Veterinary Clinics of North America. Small Animal Practice·Vicki L Campbell
Mar 5, 2002·The Tohoku Journal of Experimental Medicine·K YasuokaG Takada
Jun 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H SabaG Burnstock
Apr 13, 2004·Journal of Cardiovascular Pharmacology·Alexander NapPieter A van Zwieten
Aug 1, 1979·Circulation Research·N M BuckleyP Brazeau
Jan 1, 1989·Pharmacotherapy·V Bhatt-Mehta, M C Nahata
Oct 12, 1999·The American Journal of Physiology·W J PearceJ Buchholz
Aug 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J Buchholz, S P Duckles
Feb 1, 1978·The American Journal of Physiology·H C Stanton, S K Woo

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