The development of the dorsal mesentery in human embryos and fetuses

Seminars in Cell & Developmental Biology
Jill Pjm HikspoorsWouter H Lamers

Abstract

The vertebrate intestine has a continuous dorsal mesentery between pharynx and anus that facilitates intestinal mobility. Based on width and fate the dorsal mesentery can be subdivided into that of the caudal foregut, midgut, and hindgut. The dorsal mesentery of stomach and duodenum is wide and topographically complex due to strong and asymmetric growth of the stomach. The associated formation of the lesser sac partitions the dorsal mesentery into the right-sided "caval fold" that serves as conduit for the inferior caval vein and the left-sided mesogastrium. The thin dorsal mesentery of the midgut originates between the base of the superior and inferior mesenteric arteries, and follows the transient increase in intestinal growth that results in small-intestinal looping, intestinal herniation and, subsequently, return. The following fixation of a large portion of the abdominal dorsal mesentery to the dorsal peritoneal wall by adhesion and fusion is only seen in primates and is often incomplete. Adhesion and fusion of mesothelial surfaces in the lesser pelvis results in the formation of the "mesorectum". Whether Toldt's and Denonvilliers' "fasciae of fusion" identify the location of the original mesothelial surfaces or, alternati...Continue Reading

Citations

Oct 23, 2019·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Yi WuWouter H Lamers
Jun 28, 2020·Journal of Anatomy·Nutmethee KruepungaWouter H Lamers
Apr 23, 2020·International Journal of Molecular Medicine·Antonios KostourosJohn Tsiaoussis
Oct 14, 2020·Development·Julia GrzymkowskiNanette Nascone-Yoder
Aug 20, 2021·Communications Biology·Kevin G ByrnesJ Calvin Coffey

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