The development of the intrinsic functional connectivity of default network subsystems from age 3 to 5

Brain Imaging and Behavior
Yaqiong XiaoFucang Jia

Abstract

In recent years, research on human functional brain imaging using resting-state fMRI techniques has been increasingly prevalent. The term "default mode" was proposed to describe a baseline or default state of the brain during rest. Recent studies suggested that the default mode network (DMN) is comprised of two functionally distinct subsystems: a dorsal-medial prefrontal cortex (DMPFC) subsystem involved in self-oriented cognition (i.e., theory of mind) and a medial temporal lobe (MTL) subsystem engaged in memory and scene construction; both subsystems interact with the anterior medial prefrontal cortex (aMPFC) and posterior cingulate (PCC) as the core regions of DMN. The present study explored the development of DMN core regions and these two subsystems in both hemispheres from 3- to 5-year-old children. The analysis of the intrinsic activity showed strong developmental changes in both subsystems, and significant changes were specifically found in MTL subsystem, but not in DMPFC subsystem, implying distinct developmental trajectories for DMN subsystems. We found stronger interactions between the DMPFC and MTL subsystems in 5-year-olds, particularly in the left subsystems that support the development of environmental adaptation...Continue Reading

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Citations

Oct 30, 2016·Neuroscience and Biobehavioral Reviews·Sally RichmondSarah Whittle
Aug 17, 2016·Brain Connectivity·Chao ZhangAndrew M Michael
Jan 20, 2017·Frontiers in Psychiatry·Jocelyn V HullJohn Darrell Van Horn
Nov 14, 2018·Chronic Stress·Keila RebelloJoão R Sato

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