The development of the plutonium lung clearance model for exposure estimation of the Mayak production association, nuclear plant workers

Health Physics
V F KhokhryakovM P Krahenbuhl

Abstract

The purpose of this study was to develop a biokinetic model that uses urinary plutonium excretion rate data to estimate the plutonium accumulation in the human respiratory tract after occupational exposure. The model is based on autopsy and urinalysis data, specifically the plutonium distribution between the respiratory tract and the remainder of the body, taken from 543 former workers of a radiochemical facility at the Mayak Production Association (MPA) plant. The metabolism of plutonium was represented with a compartmental model, which considers individual exposure histories and the inherent solubility properties of industrial plutonium aerosols. The transport properties of plutonium-containing aerosols were estimated by experimentally defining their in vitro solubility. The in vitro solubilities were found by dialysis in a Ringer's solution. Analysis of the autopsy data indicated that a considerable fraction of the inhaled plutonium is systemically redistributed rapidly after inhalation. After the initial dynamic period, a three-compartment model describes the retention in the respiratory tract. One compartment describes the nuclide retained in the lungs, the second compartment describes a plutonium lung concentration that e...Continue Reading

References

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Citations

Aug 12, 2008·Radiation Protection Dosimetry·G MillerY V Zaytseva
Jul 30, 2014·International Journal of Radiation Biology·James W MarshMargot Tirmarche
Dec 31, 2004·Radiation Research·E S GilbertS A Romanov
Apr 8, 2003·American Journal of Human Genetics·M Prakash HandeDavid J Brenner
Apr 7, 2021·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Khaled TalaatJinxiang Xi

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