PMID: 9555612Apr 29, 1998Paper

The development of treatment resistance in patients with schizophrenia: a clinical and pathophysiologic perspective

Journal of Clinical Psychopharmacology
J LiebermanS Keith

Abstract

The pathophysiologic process and clinical factors that contribute to the development of treatment resistance in schizophrenia are not well defined. This article describes data indicating that treatment resistance may evolve over the course of the patients' illness and maturational development. Data from multiepisode patients suggest that early effective intervention with clozapine can prevent treatment resistance. Early identification of patients with signs of treatment resistance is vital. Treatments must be effective and prevent relapse. At the first indication that a patient may be developing resistance (e.g., the emergence of extrapyramidal symptoms or increases in negative symptomatology) or may not be complying with treatment, clozapine therapy should be considered.

Citations

Aug 11, 2007·International Clinical Psychopharmacology·A Carlo AltamuraHerbert Y Meltzer
Sep 15, 2009·Primary Care Companion to the Journal of Clinical Psychiatry·Prakash S MasandJohn M Kane
Jan 25, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Rebecca Schennach-WolffMichael Riedel
Aug 28, 2007·The Psychiatric Clinics of North America·Matthew J ByerlyEmmeline Lescouflair
Sep 30, 2005·The European Journal of Neuroscience·Eric W BrunskillCharles V Vorhees
Aug 2, 2005·Schizophrenia Research·W Wolfgang FleischhackerUNKNOWN EUFEST Steering Committee
Nov 21, 2014·CNS Spectrums·Martin T Strassnig, Philip D Harvey
Aug 4, 2004·International Clinical Psychopharmacology·Siegfried KasperAndrew Martin Jones
Jan 27, 2010·International Clinical Psychopharmacology·Wayne MacfaddenJohn Thomas Haskins
Apr 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jeffrey A LiebermanRobert M Hamer
Sep 26, 2012·Clinical Schizophrenia & Related Psychoses·Herbert Y Meltzer
May 30, 2013·Molecular Pharmacology·Jordan MarroccoFerdinando Nicoletti
Feb 15, 2007·The Journal of Nervous and Mental Disease·Jonathan D Prince
Feb 24, 2006·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Ashok K MallaRidha Joober
Jul 1, 2010·Expert Opinion on Pharmacotherapy·Ofer AgidGary Remington
Oct 23, 2010·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Ofer AgidGary Remington
Jan 1, 2008·International Journal of Psychiatry in Clinical Practice·Lars HelldinTrevor Archer
Sep 17, 2020·Psychiatry Journal·Zaina P QureshiHollie M L Bailey
Nov 10, 2020·Der Nervenarzt·Roman Knorr, Klaus Hoffmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.