The developmental competence of mammalian oocytes: a convenient but biologically fuzzy concept

Theriogenology
V Duranthon, J P Renard

Abstract

Oocyte developmental competence is often used to qualify in vitro procedures for embryo production. It supposedly accounts for the oocyte's ability to develop into a normal, viable and fertile offspring after fertilization, but for practical reasons it often characterizes the ability of such oocytes to develop to the blastocyst stage in vitro. Molecular tools compatible with the analysis of very small amounts of material have resulted in research aimed at designing molecular criteria to define this competence. However we feel that such research strategies easily lead to misunderstanding of the regulative processes that drive embryo development. Artificially induced blastocyst stage is a poor predictor of oocyte developmental competence. However preimplantation stages also appear to be sensitive to environmental conditions that can induce long-lasting detrimental effects. Larger scale analysis now made available by a functional genomics approach provides a more accurate understanding of the complex regulative networks that sustain the molecular mechanisms responsible for normal development. We propose that the concept of developmental competence should be used more cautiously and also should refer more explicitly to the experime...Continue Reading

References

Mar 1, 1991·Molecular Reproduction and Development·V RichouxC Babinet
May 1, 1990·Molecular Reproduction and Development·N A TelfordG A Schultz
Mar 1, 1988·Journal of Reproduction and Fertility·I M CrosbyR M Moor
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J Van Blerkom
Jan 1, 1980·Developmental Biology·R Bachvarova, V De Leon
May 1, 1995·Experimental Cell Research·C BouniolP Debey
Jun 1, 1995·Molecular Reproduction and Development·G O Babalola, R M Schultz
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·E DulioustM Auroux
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·D RiethmacherC Birchmeier
Jul 1, 1994·Journal of Reproduction and Fertility·B GrisartF Dessy
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·L LarueR Kemler
Apr 1, 1993·Developmental Biology·P T Ram, R M Schultz
Jan 1, 1996·Molecular Reproduction and Development·D K Barnett, B D Bavister
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·A C VerrottiM Wickens
Feb 1, 1996·Molecular Reproduction and Development·H Murakami, H Imai
Jan 1, 1997·Journal of Reproduction and Fertility·M Lane, D K Gardner
Apr 1, 1997·Current Biology : CB·I RoemerJ Klose
Nov 26, 1998·Reviews of Reproduction·L E YoungI Wilmut
May 8, 1999·Lancet·J P RenardX Vignon
Aug 17, 1999·Current Opinion in Genetics & Development·R L Gardner
Sep 24, 1999·Biology of Reproduction·R BoniB Dale

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Citations

Mar 3, 2004·Reproductive Biomedicine Online·Ri-Cheng ChianSeang-Lin Tan
Dec 21, 2002·Biology of Reproduction·Teija T PeuraSimon K Walker
May 29, 2002·Current Opinion in Obstetrics & Gynecology·Helen M Picton
Mar 30, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Isabelle GilbertMarc-André Sirard
Nov 16, 2013·Molecular Human Reproduction·Rémi Labrecque, Marc-André Sirard
Jun 27, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Mike DiederichHeiner Niemann
Jul 3, 2003·Médecine sciences : M/S·Elisabeth S Christians
Sep 21, 2006·Reproductive Biomedicine Online·A AliP Miron
Jun 6, 2009·Cytokine & Growth Factor Reviews·Wendy V Ingman, Sarah A Robertson
May 8, 2007·Theriogenology·P J Chenoweth
Dec 5, 2006·Animal Reproduction Science·T A L BreviniF Gandolfi
Oct 16, 2014·Zygote : the Biology of Gametes and Early Embryos·Bartosz KempistyMaciej Zabel
Jun 26, 2015·Scientific Reports·Xing DuanShao-Chen Sun
Oct 1, 2004·Molecular Reproduction and Development·Tiziana A L BreviniF Gandolfi
Jul 25, 2008·Reproduction in Domestic Animals = Zuchthygiene·P MermillodP Monget
Aug 31, 2006·Molecular Reproduction and Development·G G LeoniS Naitana
Aug 24, 2013·Reproduction in Domestic Animals = Zuchthygiene·C Wrenzycki, H Stinshoff
Nov 15, 2006·Animal Reproduction Science·C E FarinS Kennedy-Stoskopf
Jan 20, 2006·Reproduction in Domestic Animals = Zuchthygiene·A M TarazonaM Olivera-Angel
Jul 9, 2009·Journal of Zhejiang University. Science. B·Li-ya WangChen-ming Xu
Jun 22, 2017·Zygote : the Biology of Gametes and Early Embryos·Hyuk-Joon JeonJeong Su Oh
Dec 10, 2002·Reproductive Biomedicine Online·J M Cummins

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