Apr 1, 1984

The developmental expression of neurofilament and glial filament proteins in the human pituitary gland: an immunohistochemical study with monoclonal antibodies

Brain Research
J Q TrojanowskiV M Lee

Abstract

Monoclonal antibodies (MA) specific for neurofilaments (NF) and glial filaments (GF) were used to study the development of the normal human pituitary gland in fetuses, premature infants and adults. A total of 16 serially sectioned pituitary glands was examined. The expression of both NF and GF proteins correlated with maturation of the pituitary gland. Axons, but not cell bodies, were observed to contain immunoreactive NF proteins and these labeled axons were restricted almost exclusively to the pars nervosa. However, in early stages of development, intra-axonal NF proteins were not detectable. Aggregates of NF material in ' blobs ' were also observed in the pars nervosa of adults and a premature infant who survived 6 months following birth. They were never observed in more immature pituitary glands. Cells containing immunoreactive GF proteins were present in all subdivisions of the pituitary gland and they were more common in later stages of development. However, such cells represented only a minority of those present in the pituitary gland and cells in the pars distalis did not express GF protein until after birth. ' Blobs ' comprised of immunoreactive GF proteins were also seen. They were restricted to the pars nervosa and a...Continue Reading

Mentioned in this Paper

Monoclonal Antibodies
Monoclonal antibodies, antineoplastic
Neurofilament
Immunologic Deficiency Syndromes
Glial Fibrillary Acidic Protein
Infundibular Stem
Biologic Development
Neuroglia
Cell Differentiation Process
Axon

About this Paper

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a chronic neurodegenerative disease. This feed focuses on the underlying role of Tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's.

ALS & FTD: TDP-43

ALS shares with a considerable proportion of FTD cases the same neuropathological substrate, namely, inclusions of abnormally phosphorylated protein tdp-43 (ptdp-43). Here are the latest discoveries pertaining to ptdp-43 and these diseases.