PMID: 3755818Aug 11, 1986Paper

The developmental expression of the gene for TFIIIA in Xenopus laevis

Nucleic Acids Research
W L TaylorD D Brown

Abstract

The sequence of the trans-acting positive transcription factor TFIIIA has been deduced by sequencing cDNA and genomic DNA clones. Using DNA from a homozygous diploid animal we show that there is one gene for TFIIIA per haploid genome of X. laevis. Protein sequencing of proteolytic fragments of TFIIIA orients the protein in its interaction with the internal control region (ICR) of the 5S RNA gene. The protein lies along the DNA with its carboxyl terminus at the 5' end of the ICR and its amino terminus at the 3' end. The developmental pattern of TFIIIA and its mRNA during oogenesis and embryogenesis are consistent with the idea that the abundance of TFIIIA plays an essential role in the developmental change in 5S RNA gene expression. The change to almost exclusive somatic 5S RNA gene expression by gastrulation occurs using either the TFIIIA that was synthesized by oocyte and/or TFIIIA synthesized from maternal mRNA.

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Citations

Sep 6, 2003·Gene·David GriffinWilliam L Taylor
Feb 21, 2002·The Biochemical Journal·Cara J WestmarkPaul W Huber
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R S BrownK R Leonard
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S R Tafuri, A P Wolffe
May 11, 1988·Nucleic Acids Research·Y Matsumoto, L J Korn
Nov 13, 2012·Biochimica Et Biophysica Acta·Elodie LayatSylvette Tourmente
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·R T NolteR S Brown
Feb 16, 2002·Developmental Biology·Irina StanchevaRichard R Meehan
Oct 5, 2010·Cell Cycle·Hélène Dumay-OdelotMartin Teichmann
Aug 5, 2003·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Zungyoon Yang, Jeffrey J Hayes
Jun 25, 1998·Molecular and Cellular Biology·S L Pfaff, W L Taylor
Apr 1, 1988·Molecular and Cellular Biology·K E VranaD D Brown

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