PMID: 8614262Jan 1, 1996Paper

The developmental increase of the AT1A, but not the AT1B, receptor mRNA level at the preoptic area in spontaneously hypertensive rats

Life Sciences
C KomatusT Furukawa

Abstract

To determine the possible involvement of the central angiotensin system in hypertension, the angiotensin II type-1 receptor subtype mRNA levels in the preoptic area (POA) and hypothalamus were measured by means of a reverse-transcriptase/polymerase chain reaction in spontaneously hypertensive rats (SHR), and the results were then compared with the findings in age-matched normotensive Wistar-Kyoto rats (WKY). In 4-week-old (prehypertensive stage) and 7-week-old (evolving stage) SHR, the AT1A and AT1B receptor subtype mRNA levels in the POA and hypothalamus did not show any significant difference between the SHR and WKY. However, in the 16-week-old SHR (hypertensive stage), AT1A receptor subtype mRNA at POA was approximately 2-fold higher than in the WKY, while the AT1B receptor subtype mRNA showed no difference. On the other hand, neither the AT1A nor the AT1B mRNA level at the hypothalamus were different between the 16-week-old SHR and WKY. These results suggest that the AT1A mRNA level, but not the AT1B mRNA level, increases in the POA in hypertensive stage of SHR and the increase may therefore be related in some way to the state of hypertension.

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Citations

Mar 14, 2013·Bulletin of Experimental Biology and Medicine·L O KlimovA L Markel
Sep 2, 2006·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Takao Kubo
Apr 5, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshie KambeTakao Kubo
Sep 24, 2015·Neuropeptides·Patrícia M FerreiraMaria J Campagnole-Santos
Feb 6, 2004·Clinical and Experimental Pharmacology & Physiology·Toshie KambeTakao Kubo
Jul 13, 2004·Experimental Neurology·Yanfang ChenMariana Morris
Feb 20, 2003·Brain Research·Yanfang ChenMariana Morris
May 29, 2003·British Journal of Pharmacology·Shereeni J Veerasingham, Mohan K Raizada
Nov 1, 2012·Medical History·Vivian Nutton

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