The 'Developmental Origins' Hypothesis: relevance to the obstetrician and gynecologist

Journal of Developmental Origins of Health and Disease
A J KermackN S Macklon

Abstract

The recognition of 'fetal origins of adult disease' has placed new responsibilities on the obstetrician, as antenatal care is no longer simply about ensuring good perinatal outcomes, but also needs to plan for optimal long-term health for mother and baby. Recently, it has become clear that the intrauterine environment has a broad and long-lasting impact, influencing fetal and childhood growth and development as well as future cardiovascular health, non-communicable disease risk and fertility. This article looks specifically at the importance of the developmental origins of ovarian reserve and ageing, the role of the placenta and maternal nutrition before and during pregnancy. It also reviews recent insights in developmental medicine of relevance to the obstetrician, and outlines emerging evidence supporting a proactive clinical approach to optimizing periconceptional as well as antenatal care aimed to protect newborns against long-term disease susceptibility.

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Citations

May 18, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A RamosR Corcoy
Jul 4, 2018·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Laura BrouwersPeter Gj Nikkels
Dec 28, 2018·The Journal of Clinical Endocrinology and Metabolism·Jacob P ChristBart C J M Fauser
Apr 30, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M N GunningB C J M Fauser
Mar 28, 2017·Frontiers in Public Health·Luchuo Engelbert Bain, Ikenna Desmond Ebuenyi

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