PMID: 8954748Dec 1, 1996Paper

The developmental toxicity of boric acid in rabbits

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
C J PriceB A Schwetz

Abstract

Boric acid (BA), an ingredient of many pharmaceutical, cosmetic, and pesticide products, was previously shown to induce reproductive and developmental toxicity in laboratory rodents. In this study, BA (0, 62.5, 125, or 250 mg/kg/day, po) was administered on Gestational Days (GD) 6-19 to New Zealand White rabbits (18-23 pregnant/group). Maternal body weight, food consumption, and clinical condition were monitored at regular intervals throughout gestation. At termination (GD 30), the numbers of uterine implantations, resorptions, dead fetuses, and live fetuses were determined. Fetuses were weighed, and live fetuses examined for external, visceral, and skeletal defects. Maternal food intake decreased during treatment at 250 mg/kg/day and increased at >/=125 mg/kg/day after treatment. Maternal body weight (GD 9-30), weight gain during treatment, gravid uterine weight, and number of ovarian corpora lutea decreased at 250 mg/kg/day. In contrast, maternal corrected gestational weight gain increased at >/=125 mg/kg/day. Maternal liver weight was not affected. Relative (but not absolute) maternal kidney weight increased at 250 mg/kg/day, and microscopic evaluation revealed no treatment-related renal pathology. At 250 mg/kg/day, prenatal...Continue Reading

Citations

Mar 2, 1999·Biological Trace Element Research·C J PriceM M Goldberg
Aug 21, 2012·Environmental Monitoring and Assessment·Enn Karro, Marge Uppin
Oct 19, 2007·Biological Trace Element Research·Yadong WangXiaoyu Chen
Nov 25, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R KroesUNKNOWN European branch of the International Life Sciences Institute
Jul 20, 2002·Reproductive Toxicology·Jana W Cherrington, Neil Chernoff
Feb 6, 2016·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·L David Wise
Jan 24, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Robert L SprandoMartine Ferguson
Nov 10, 2012·Regulatory Toxicology and Pharmacology : RTP·Ryuichi HasegawaAkihiko Hirose
Oct 28, 2015·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·M C Buser, H R Pohl
May 17, 2003·Birth Defects Research. Part A, Clinical and Molecular Teratology·Nathalie WéryFrançoise Gofflot
Oct 21, 2005·Environmental Geochemistry and Health·Chadi YazbeckGuy Huel
Dec 25, 2007·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Rochelle W TylJohn M Rogers
May 16, 2009·Environmental Monitoring and Assessment·Ren-ji XuFu-sheng Wei
Apr 22, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Shujie LiuJunichi Tasaki
Apr 11, 2007·The British Journal of Nutrition·Mehmet KorkmazSiddik Keskin
Jan 25, 2021·Regulatory Toxicology and Pharmacology : RTP·Niels HadrupAnoop K Sharma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
J J HeindelB A Schwetz
Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
P A FailJ J Heindel
© 2021 Meta ULC. All rights reserved