"The devil's in the detail": Release of an expanded, enhanced and dynamically revised forensic STR Sequence Guide

Forensic Science International. Genetics
C PhillipsWalther Parson

Abstract

The STR sequence template file published in 2016 as part of the considerations from the DNA Commission of the International Society for Forensic Genetics on minimal STR sequence nomenclature requirements, has been comprehensively revised and audited using the latest GRCh38 genome assembly. The list of forensic STRs characterized was expanded by including supplementary autosomal, X- and Y-chromosome microsatellites in less common use for routine DNA profiling, but some likely to be adopted in future massively parallel sequencing (MPS) STR panels. We outline several aspects of sequence alignment and annotation that required care and attention to detail when comparing sequences to GRCh37 and GRCh38 assemblies, as well as the necessary matching of MPS-based allele descriptions to previously established repeat region structures described in initial sequencing studies of the less well known forensic STRs. The revised sequence guide is now available in a dynamically updated FTP format from the STRidER website with a date-stamped change log to allow users to explore their own MPS data with the most up-to-date forensic STR sequence information compiled in a simple guide.

Citations

May 12, 2018·Electrophoresis·Antonio AlonsoBruce Budowle
Sep 18, 2018·Electrophoresis·Rachel HoustonDavid Gangitano
Nov 21, 2019·International Journal of Legal Medicine·Petra MüllerUNKNOWN SeqForSTR-Consortium
May 27, 2020·International Journal of Legal Medicine·David BallardJoanna Wesoły
Jun 7, 2019·International Journal of Legal Medicine·Barbara Karolina ZajacMelanie Weissenberger
Nov 16, 2019·Scientific Reports·Hussain M AlsafiahWilliam Goodwin
Jan 2, 2021·Forensic Science International : Synergy·John M Butler, Sheila Willis
Jan 28, 2020·Forensic Science International. Genetics·Janine SilveryCarsten Tiemann
Feb 24, 2020·Forensic Science International. Genetics·Cláudia GomesEduardo Arroyo-Pardo
Feb 26, 2021·Molecular Genetics & Genomic Medicine·Hui LiJianhui Xie
Oct 13, 2018·Forensic Science International. Genetics·Brian A YoungPeter M Vallone
Feb 20, 2021·Forensic Science International. Genetics·Jerry HoogenboomKristiaan J van der Gaag
Oct 7, 2019·Forensic Science International. Genetics·Katherine Butler GettingsChristopher Phillips
Apr 2, 2021·Emerging Topics in Life Sciences·Penelope R Haddrill
Jun 13, 2020·Forensic Science International. Genetics·Deborah S B S SilvaSeth A Faith
Aug 12, 2021·International Journal of Legal Medicine·Jianye GeBruce Budowle
Aug 27, 2021·International Journal of Legal Medicine·Petra Hölzl-MüllerWalther Parson

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