The dexamethasone corticotropin releasing hormone test in healthy and depressed women with and without childhood adversity

Psychoneuroendocrinology
Carsten SpitzerKatja Wingenfeld

Abstract

Alterations of the hypothalamic-pituitary-adrenal (HPA) axis are a prominent finding in patients with major depressive disorder (MDD). Inconsistencies regarding a hyper- or hypoactive HPA axis may be explained by the moderating effect of childhood adverse experiences (ACE) which are associated with both HPA axis dysfunction and MDD in adulthood. We aimed to systematically disentangle the effects of ACE and MDD on HPA axis by comparing healthy women with and without childhood adversity and women with MDD with and without ACE. The dexamethasone/corticotropin-releasing hormone (DEX/CRH) test was administered in 35 women with MDD and ACE as determined by a clinical interview (SCID, Early Trauma Inventory), 51 women with MDD without ACE, 21 women with ACE but no current or lifetime MDD and 37 healthy women without either MDD or ACE. There were no group differences in age, smoking, body mass index, and intake of oral contraceptives. Free salivary cortisol responses were not significantly different between the four groups. This study shows no evidence for a dysregulation of the HPA axis as measured by the DEX/CRH test in depressed women with and without childhood adversity as compared to mentally healthy women with or without early li...Continue Reading

References

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Apr 21, 2009·Biological Psychiatry·Linda L CarpenterLawrence H Price
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Jun 17, 2015·European Psychiatry : the Journal of the Association of European Psychiatrists·L MandelliA Serretti

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Citations

Nov 28, 2020·European Journal of Psychotraumatology·Michael KaczmarczykChristian Otte
May 1, 2021·Brain Sciences·Michael SchaeferSören Enge

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