The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila.

Cell Metabolism
Matthew H Sieber, Carl S Thummel

Abstract

Triacylglycerol (TAG) homeostasis is an integral part of normal physiology and essential for proper energy metabolism. Here we show that the single Drosophila ortholog of the PXR and CAR nuclear receptors, DHR96, plays an essential role in TAG homeostasis. DHR96 mutants are sensitive to starvation, have reduced levels of TAG in the fat body and midgut, and are resistant to diet-induced obesity, while DHR96 overexpression leads to starvation resistance and increased TAG levels. We show that DHR96 function is required in the midgut for the breakdown of dietary fat and that it exerts this effect through the CG5932 gastric lipase, which is essential for TAG homeostasis. This study provides insights into the regulation of dietary fat metabolism in Drosophila and demonstrates that the regulation of lipid metabolism is an ancestral function of the PXR/CAR/DHR96 nuclear receptor subfamily.

References

Jan 1, 1991·Annual Review of Entomology·W H Telfer, J G Kunkel
Dec 1, 1990·Gut·M LigumskyR Goldstein
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·G J Fisk, C S Thummel
Mar 24, 2000·Pharmacotherapy·A M HeckK A Calis
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Dec 1, 2001·Science·A ChawlaD J Mangelsdorf
Jul 18, 2002·Nature Reviews. Drug Discovery·Timothy M Willson, Steven A Kliewer
Apr 5, 2003·Current Biology : CB·Sebastian GrönkeRonald P Kühnlein
Mar 9, 2004·The Journal of Biological Chemistry·Jodi M MaglichJohn T Moore
Oct 19, 2004·Genes & Development·Yuriy ShostakKeith R Yamamoto
Aug 2, 2005·Cell Metabolism·Sebastian GrönkeRonald P Kühnlein
Nov 10, 2005·Nature Methods·Gil B CarvalhoSeymour Benzer
Mar 16, 2006·Journal of Cell Science·Matthew D Phillips, Graham H Thomas
Jun 21, 2006·The Journal of Cell Biology·Krista M HennigThomas P Neufeld
Jul 4, 2006·Cell Metabolism·Kirst King-JonesCarl S Thummel
Aug 18, 2006·Development·Laura PalankerHenry M Krause
Feb 8, 2007·Steroids·Yoav E Timsit, Masahiko Negishi
Mar 7, 2007·Cell Metabolism·Stephen P VoghtLeo J Pallanck
May 10, 2007·PLoS Biology·Sebastian GrönkeRonald P Kühnlein
May 31, 2007·Nature Genetics·Venkateswara R ChintapalliJulian A T Dow
Nov 21, 2007·FEBS Letters·Junichiro SonodaRonald M Evans
Dec 11, 2008·Annual Review of Entomology·Dwayne HegedusUmut Toprak
Mar 4, 2009·Cell Metabolism·Laura PalankerCarl S Thummel
Mar 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·Henry ChungPhillip J Daborn
Dec 3, 2009·Genes & Development·Michael A HornerCarl S Thummel

❮ Previous
Next ❯

Citations

Mar 30, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Laura Michelle BeaverJadwiga Maria Giebultowicz
Nov 26, 2009·Molecular and Cellular Biology·Mattéa BujoldKirst King-Jones
Mar 5, 2013·Physiology·Irene Trinh, Gabrielle L Boulianne
Mar 9, 2013·Disease Models & Mechanisms·Manivannan SubramanianGaiti Hasan
May 8, 2013·Disease Models & Mechanisms·Jessica L BuescherJennifer G Duncan
Sep 21, 2011·PloS One·Anja HildebrandtRonald P Kühnlein
Jan 6, 2011·Journal of Visualized Experiments : JoVE·Mariya M KucherenkoHalyna R Shcherbata
Apr 19, 2011·Annual Review of Biochemistry·Joshua Wollam, Adam Antebi
Apr 29, 2014·Trends in Endocrinology and Metabolism : TEM·Divya Padmanabha, Keith D Baker
Jan 29, 2013·The Journal of Biological Chemistry·Laura Palanker MusselmanThomas J Baranski
May 22, 2013·The Journal of Cell Biology·Tiffiney R HartmanAlana M O'Reilly
Apr 3, 2012·Aquatic Toxicology·Elina KarimullinaWilliam S Baldwin
May 31, 2011·Progress in Lipid Research·Ronald P Kühnlein
Jan 21, 2016·Proceedings of the National Academy of Sciences of the United States of America·Sonita AfscharLinda Partridge
Sep 30, 2014·Cell Reports·Wei SongNorbert Perrimon
Jun 18, 2011·Pest Management Science·Sheetal ShahStephen Hadfield
Sep 19, 2015·Critical Reviews in Biochemistry and Molecular Biology·Julia Marianne Hoffmann, Linda Partridge
Aug 6, 2014·General and Comparative Endocrinology·Yangchun LiWilliam S Baldwin
May 23, 2015·Nature Communications·Rupali UgrankarJonathan M Graff
Jul 28, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Rita T Brookheart, Jennifer G Duncan
Oct 5, 2016·Gene·David MajerowiczKatia C Gondim
Jan 4, 2017·PloS One·Ayako Kohyama-KoganeyaYoshio Hirabayashi
Dec 7, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A C ColpoV Folmer
Jan 16, 2018·Nuclear Receptor Research·Shari BodofskyBruce Wightman
Feb 20, 2019·FEBS Letters·Pinreddy KarunakarAbhay Sharma
Mar 23, 2013·Molecular Pharmacology·Robert N HelsleyChangcheng Zhou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.