The Diabetes Risk Phenotype of Young Women With Recent Gestational Diabetes

The Journal of Clinical Endocrinology and Metabolism
Marietta RottenkolberAndreas Lechner

Abstract

The pathogenesis of type 2 diabetes (T2D) is still incompletely understood. In-depth phenotyping of young individuals at risk for T2D can contribute to the understanding of this process. The purpose of this study was to metabolically characterize women with recent gestational diabetes (GDM), an at-risk cohort for T2D. Participants were 147 women consecutively recruited 3 to 16 months after pregnancy: women who had GDM and women after a normoglycemic pregnancy (control subjects) in a 2:1 ratio. This was a monocenter cross-sectional analysis (Prediction, Prevention and Subclassification of Type 2 Diabetes Study [PPS-Diab]). A 5-point oral glucose tolerance test with calculation of the insulin sensitivity index and disposition index (validation by euglycemic clamp and intravenous glucose tolerance test) was performed. In addition, anthropometrics, medical and family history, clinical chemistry and biomarkers, statistical modeling, and a magnetic resonance imaging/magnetic resonance spectroscopy substudy (body fat distribution and liver and muscle fat; n = 66) were obtained. Compared with control subjects, women after GDM had a reduced disposition index, higher levels of plasma fetuin-A, and a lower insulin sensitivity index. A low...Continue Reading

Citations

Mar 1, 2016·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Felicitas MaierOlaf Uhl
Aug 17, 2016·Epigenomics·Joanna D Holbrook
Oct 19, 2017·Diabetic Medicine : a Journal of the British Diabetic Association·F BanningA Lechner
Jun 14, 2018·The Journal of Clinical Endocrinology and Metabolism·Lakmini PinnaduwageRavi Retnakaran
Jun 28, 2018·The Journal of Clinical Endocrinology and Metabolism·Daniel PoppNora N Sommer
Jan 9, 2020·Journal of Diabetes Investigation·Greg E TutinoRonald Cw Ma
Dec 16, 2017·The Journal of Clinical Endocrinology and Metabolism·Christina GarAndreas Lechner
Aug 16, 2017·Endocrine·Ida PastoreAntonio Brunetti
Dec 31, 2019·Journal of Diabetes Research·Angelika Sobota-GrzeszykJacek Szamatowicz
Aug 9, 2020·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Sabrina ReifAndreas Lechner
Jan 31, 2021·The Journal of Clinical Endocrinology and Metabolism·Marietta RottenkolberAndreas Lechner
Jun 5, 2021·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Zixin CaiJingjing Zhang
Aug 19, 2021·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Stefanie Kern-MatschillesAndreas Lechner

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