PMID: 16522279Mar 9, 2006Paper

The diabetic myocardium

Current Diabetes Reports
Thomas H Marwick

Abstract

Heart failure and diabetes mellitus are frequently associated, with diabetes potentiating the development of heart failure after other myocardial insults. This review documents the evidence in support of a specific primary myocardial disease in diabetes. The strongest clinical evidence relates to the detection of otherwise unexplained diastolic dysfunction in apparently healthy diabetic subjects, but recent studies with sensitive echocardiographic markers have shown systolic disturbances as well. The mechanism of this myocardial disease is multifactorial, with contributions from metabolic effects on the myocyte, structural changes in the myocardium and interstitium, autonomic neuropathy, and perhaps coronary vascular disease. The common pathway appears to be related to glycemic control and new evidence suggests better metabolic control to be beneficial, as well as angiotensin-converting enzyme inhibition and cross-link breakers.

References

May 11, 1979·JAMA : the Journal of the American Medical Association·W B Kannel, D L McGee
Aug 1, 1979·Diabetes·V W FischerM L Leskiw
Mar 1, 1977·British Heart Journal·C A SykesB L Pentecost
Mar 1, 1991·Diabetes Research and Clinical Practice·Y KitaR Takeda
Nov 8, 1972·The American Journal of Cardiology·S RublerA Grishman
Dec 1, 1982·The American Journal of Medicine·N E FriedmanP Chiemmongkoltip
Sep 1, 1980·British Heart Journal·L M ShapiroJ Mackinnon
Nov 1, 1993·Journal of the American College of Cardiology·K C AllmanM Schwaiger
Jun 1, 1996·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·M MäntysaariM Uusitupa
Feb 14, 1998·Journal of the American College of Cardiology·R ScognamiglioS Dalla Volta
Aug 4, 1999·Journal of Diabetes and Its Complications·J I MaloneE Gilbert-Barness
Mar 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·M AsifT J Regan
Apr 26, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·F FiordalisoJ Kajstura
Jan 9, 2003·JAMA : the Journal of the American Medical Association·Margaret M RedfieldRichard J Rodeheffer
Feb 25, 2003·Journal of the American College of Cardiology·Zhi You FangThomas H Marwick
Aug 9, 2003·Journal of the American College of Cardiology·Zhi You FangThomas H Marwick
Aug 30, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Jing LiuAshwani Malhotra
Feb 18, 2004·Heart·Miles Fisher
Mar 31, 2004·The American Journal of Cardiology·John K BoyerJulio E Pérez
Apr 16, 2004·European Heart Journal·Pascal De GrooteChristophe Bauters
Jan 13, 2005·Diabetologia·Z Y FangT H Marwick
Apr 23, 2005·American Heart Journal·Zhi You FangThomas H Marwick
Jun 29, 2005·Diabetes Care·Zhi You FangThomas H Marwick

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