PMID: 9552583Jan 1, 1996Paper

The diagnosis and clinical manifestations of activated protein C resistance: a case report and review of the literature

Vascular Medicine
H D HoerlK Kottke-Marchant

Abstract

Activated protein C resistance (APCR) is a recently discovered, medically important cause of venous thrombosis. More than 95% of cases are due to factor V Leiden (FVL), a mutated form of factor V that is resistant to degradation by activated protein C. The prevalence of this disorder, which is inherited in an autosomal dominant fashion, is approximately 5% among asymptomatic people of European heritage. In addition, 20 to 60% of patient cohorts with previous thrombosis demonstrate APCR, making it the most common known genetic cause of abnormal thrombophilia. Current laboratory techniques available for diagnosis include functional assays, such as the APC ratio, as well as DNA-based tests that detect the specific genetic anomaly responsible for FVL. A case report is presented, along with a review of the literature highlighting epidemiology, pathogenesis, clinical features and methods for laboratory diagnosis.

References

Oct 28, 1995·Lancet·D C ReesJ B Clegg
Oct 1, 1995·American Journal of Clinical Pathology·M SamahaM M Samama
Sep 1, 1995·American Journal of Ophthalmology·R DhôteB Christoforov
Oct 22, 1994·Lancet·J I JorqueraJ Aznar
Mar 1, 1995·American Journal of Clinical Pathology·G M Rodgers
Feb 24, 1994·The New England Journal of Medicine·P J Svensson, B Dahlbäck
Mar 21, 1996·The New England Journal of Medicine·H MandelU Seligsohn

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Citations

Dec 2, 2005·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Bo XuKandice Kottke-Marchant
Feb 28, 2002·Archives of Pathology & Laboratory Medicine·Kandice Kottke-Marchant

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