The Diagnosis and Treatment of Primary CNS Lymphoma

Deutsches Ärzteblatt International
Louisa von BaumgartenMartin Dreyling

Abstract

Primary central nervous system lymphoma is a diffuse large B-celllymphoma with exclusive manifestation in the central nervous system (CNS), leptomeninges, and eyes. Its incidence is 0.5 per 100 000 persons per year.Currently, no evidence-based standard of care exists. This review is based on pertinent publications (2000-2017) retrieved by aselective search in PubMed. The clinical and neuroradiological presentation of primary CNS lymphoma isoften nonspecific, and histopathological confirmation is obligatory. The disease, if left un- treated, leads to death within weeks or months. If the patient's general condition permits, treatment should consist of a high-dose chemotherapy based on methotrexate (HD- MTX) combined with rituximab and other cytostatic drugs that penetrate the blood-brain barrier. Long-term survival can be achieved in patients under age 70 by adding non- myeloablative consolidation chemotherapy or high-dose chemotherapy with autologous stem cell transplantation (HD-AST) to the induction therapy. Clinical trials comparing the efficacy and toxicity of these two treatment strategies are currently underway. Con- solidation whole-brain radiotherapy is associated with the risk of severe neurotoxicity and should be reser...Continue Reading

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Mar 7, 2020·Frontiers in Cell and Developmental Biology·Abbye E McEwenChristina M Lockwood
May 1, 2021·Cancers·Ruben Van DijckJacoline E C Bromberg
Nov 9, 2020·Cancer Treatment and Research Communications·Antonio DonoYoshua Esquenazi
Jul 3, 2021·Cancers·Tamara Mc ErlainCristina M Branco

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