The Diagnosis of Autism Spectrum Disorder Based on the Random Neural Network Cluster

Frontiers in Human Neuroscience
Xia-An BiJianhua Dai

Abstract

As the autism spectrum disorder (ASD) is highly heritable, pervasive and prevalent, the clinical diagnosis of ASD is vital. In the existing literature, a single neural network (NN) is generally used to classify ASD patients from typical controls (TC) based on functional MRI data and the accuracy is not very high. Thus, the new method named as the random NN cluster, which consists of multiple NNs was proposed to classify ASD patients and TC in this article. Fifty ASD patients and 42 TC were selected from autism brain imaging data exchange (ABIDE) database. First, five different NNs were applied to build five types of random NN clusters. Second, the accuracies of the five types of random NN clusters were compared to select the highest one. The random Elman NN cluster had the highest accuracy, thus Elman NN was selected as the best base classifier. Then, we used the significant features between ASD patients and TC to find out abnormal brain regions which include the supplementary motor area, the median cingulate and paracingulate gyri, the fusiform gyrus (FG) and the insula (INS). The proposed method provides a new perspective to improve classification performance and it is meaningful for the diagnosis of ASD.

References

Jun 28, 2001·JAMA : the Journal of the American Medical Association·S Chakrabarti, E Fombonne
Dec 13, 2006·NeuroImage·Stefan J KiebelKarl J Friston
Jun 14, 2008·Brain : a Journal of Neurology·Katharine N ThakkarDara S Manoach
Aug 12, 2008·Schizophrenia Research·Daniel R CalabreseJohn G Csernansky
Oct 29, 2008·Journal of the International Neuropsychological Society : JINS·Tracey A KnausHelen Tager-Flusberg
Jun 23, 2009·Neuroscience and Biobehavioral Reviews·Lucina Q Uddin, Vinod Menon
Mar 3, 2010·Journal of Autism and Developmental Disorders·Kimberly A FournierJames H Cauraugh
Jun 19, 2010·Journal of Neurochemistry·Adrian L OblakGene J Blatt
Jun 26, 2010·Frontiers in Systems Neuroscience·Yan Chao-Gan, Zang Yu-Feng
Aug 13, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christine EckerDeclan G M Murphy
Mar 26, 2011·Artificial Intelligence in Medicine·Wen-Liang HungMiin-Shen Yang
Dec 25, 2012·Journal of Psychiatric Research·João Ricardo SatoChristine Ecker
Oct 15, 2013·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Carissa J CascioScott Bolton
May 23, 2014·NeuroImage·Lars KasperKlaas P Pruessmann
Jul 12, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Leanna M HernandezMirella Dapretto
Sep 23, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Tetsuya Iidaka
Jun 7, 2015·Cerebral Cortex·Martha D KaiserKevin A Pelphrey
Jul 18, 2015·Science·M I Jordan, T M Mitchell
Jul 28, 2015·Social Neuroscience·Jenny KestemontFrank Van Overwalle
Oct 24, 2015·Human Brain Mapping·Aarti NairRalph-Axel Müller
Dec 29, 2015·Developmental Cognitive Neuroscience·Brandon KeehnRalph-Axel Müller
May 21, 2016·Frontiers in Human Neuroscience·Joshua B EwenStewart H Mostofsky
May 17, 2017·Brain Connectivity·Randi H BennettAdriana Di Martino
Jul 1, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Marco PaganiFabrizio De Carli
Oct 17, 2017·NeuroImage. Clinical·Anibal Sólon HeinsfeldFelipe Meneguzzi
Jan 4, 2018·JAMA : the Journal of the American Medical Association·Guifeng XuWei Bao

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Citations

Mar 11, 2019·Journal of Autism and Developmental Disorders·Kristine M KulageArlene M Smaldone
Dec 13, 2019·Frontiers in Neuroinformatics·Taban EslamiFahad Saeed
Jun 9, 2020·Computational and Mathematical Methods in Medicine·Jinlong HuPing Li
Oct 30, 2020·Frontiers in Neuroscience·Li ZhangDaoqiang Zhang
Mar 26, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Abdoh TalebFeng Han
Jun 27, 2021·Journal of Neuroscience Methods·Ming XuJing Sui
Sep 9, 2019··Taban EslamiFahad Saeed

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Methods Mentioned

BETA
feature extraction
SMA

Software Mentioned

R
Matlab
NetViewer
Brain
ABIDE
SMA
Data Processing Assistant for Resting - State fMRI ( DPARSF

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