The diagnosis of canine visceral leishmaniasis in Brazil: Confronting old problems

Experimental Parasitology
Rômulo Pessoa-E-SilvaMilena de Paiva-Cavalcanti

Abstract

In Brazil, the main strategy adopted to contain Visceral Leishmaniasis (VL) is the controversial culling of dogs with reagent serology for Canine VL (CVL). Despite there are studies showing that significant reduction of human cases has not been observed, as well as there are works demonstrating the occurrence of false-positive results in the confirmatory test, the protocol has been maintained. Researches that can reinforce the existence and persistence of this problem, as well as bring concrete alternatives are pivotal. In this context, the aim of this work was to evaluate and compare the serological, molecular and parasitological methods employed for CVL detection in Brazil, in dogs with diverse clinical profiles, from two endemic areas of Pernambuco state. Comparisons among TR-DPP®, EIE-LVC and qPCR (animals from Goiana-PE: 91) demonstrated that agreements varied from 'poor' to 'moderate' (kappa = 0.162-0.442), and a triple agreement occurred in 61.36% (54/88) of the samples. The highest percentage of agreement was obtained between TR-DPP® and EIE-LVC within the polysymptomatic group (93.33%; 14/15). Of the 34 dogs with reagent serology from Caruaru-PE, 17 (50%) and 29 dogs (85.29%) were positive for qPCR and parasitological ...Continue Reading

Citations

Oct 3, 2019·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Jonatas Abinadabe Oliveira SilvaGílcia Aparecida de Carvalho
Jan 11, 2020·Frontiers in Cellular and Infection Microbiology·Ana Alice Maia GonçalvesRodolfo Cordeiro Giunchetti
Aug 16, 2019·Research in Veterinary Science·Juliana M MachadoEduardo A F Coelho
Apr 15, 2021·Cadernos de saúde pública·Fernanda Alvarenga Cardoso MedeirosAndreza Pain Marcelino
Oct 9, 2021·PLoS Neglected Tropical Diseases·João Gabriel G LuzLuc E Coffeng

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