The diagnosis of hepatosplenic candidiasis by DNA analysis of tissue biopsy and serum

Journal of Clinical Pathology
A KirbyJ Burnie

Abstract

Hepatosplenic candidiasis is traditionally diagnosed by blood culture, magnetic resonance imaging (MRI), and histological analysis. The limitations of these methods include: low sensitivity (blood culture) and failure to isolate the organism (MRI/histology). This report describes a case of hepatosplenic candidiasis diagnosed by simultaneous polymerase chain reaction (PCR) analysis of liver biopsy and serum. PCR of biopsy and/or serum may offer a sensitive and specific diagnostic test for hepatosplenic candidiasis. Candida species can be identified, which helps guide antifungal chemotherapy, an important aspect in this difficult to treat infection.

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Citations

Mar 1, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Themistoklis K KourkoumpetisEleftherios Mylonakis
Sep 23, 2009·Journal of Pediatric Hematology/oncology·Marie Saint-FaustNicolas Sirvent
Jun 15, 2013·Revista iberoamericana de micología·Arnaldo Lopes ColomboUNKNOWN Grupo Proyecto Épico
Jun 15, 2013·Revista iberoamericana de micología·Arnaldo Lopes ColomboUNKNOWN Latin America Invasive Mycosis Network
Dec 7, 2007·La Revue de médecine interne·M GousseffO Lortholary
May 16, 2006·Pathologie-biologie·S Anane, F Khalfallah
Nov 23, 2010·Perspectives in Public Health·Gloria A Moss
Mar 9, 2006·Clinical Orthopaedics and Related Research·Choll W KimSteven R Garfin

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