The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Marilyn S AlbertCreighton H Phelps


The National Institute on Aging and the Alzheimer's Association charged a workgroup with the task of developing criteria for the symptomatic predementia phase of Alzheimer's disease (AD), referred to in this article as mild cognitive impairment due to AD. The workgroup developed the following two sets of criteria: (1) core clinical criteria that could be used by healthcare providers without access to advanced imaging techniques or cerebrospinal fluid analysis, and (2) research criteria that could be used in clinical research settings, including clinical trials. The second set of criteria incorporate the use of biomarkers based on imaging and cerebrospinal fluid measures. The final set of criteria for mild cognitive impairment due to AD has four levels of certainty, depending on the presence and nature of the biomarker findings. Considerable work is needed to validate the criteria that use biomarkers and to standardize biomarker analysis for use in community settings.


Apr 6, 1999·Archives of Neurology·R C PetersenE Kokmen
Sep 19, 2003·Neuroimaging Clinics of North America·Kejal Kantarci, Clifford R Jack
Sep 25, 2003·Lancet Neurology·Kaj Blennow, Harald Hampel
Sep 27, 2003·Alzheimer Disease and Associated Disorders·Monika AtiyaRonald Killiany
Apr 6, 2004·Clinics in Geriatric Medicine·David A Bennett
Aug 25, 2004·Journal of Internal Medicine·R C Petersen
Feb 16, 2005·Archives of Neurology·Dennis J Selkoe
Jan 13, 2006·Archives of Neurology·William R MarkesberyDavid R Wekstein
May 10, 2006·Archives of Neurology·Ronald C PetersenEmre Kokmen
Jul 4, 2006·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Constantine G LyketsosUNKNOWN Task Force of American Association for Geriatric Psychiatry
Aug 18, 2006·Journal of Alzheimer's Disease : JAD·Gerard D Schellenberg
Mar 20, 2009·Annals of Neurology·Leslie M ShawUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 1, 2006·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·William Jagust
Jul 2, 2010·Nature Reviews. Drug Discovery·Harald HampelKaj Blennow
Oct 20, 2010·Neuron·Lars BertramRudolph E Tanzi
Apr 26, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Clifford R JackCreighton H Phelps

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