The Diagnosis-Wide Landscape of Hospital-Acquired AKI

Clinical Journal of the American Society of Nephrology : CJASN
Anne-Sophie JannotNicolas Pallet

Abstract

The exploration of electronic hospital records offers a unique opportunity to describe in-depth the prevalence of conditions associated with diagnoses at an unprecedented level of comprehensiveness. We used a diagnosis-wide approach, adapted from phenome-wide association studies (PheWAS), to perform an exhaustive analysis of all diagnoses associated with hospital-acquired AKI (HA-AKI) in a French urban tertiary academic hospital over a period of 10 years. We retrospectively extracted all diagnoses from an i2b2 (Informatics for Integrating Biology and the Bedside) clinical data warehouse for patients who stayed in this hospital between 2006 and 2015 and had at least two plasma creatinine measurements performed during the first week of their stay. We then analyzed the association between HA-AKI and each International Classification of Diseases (ICD)-10 diagnostic category to draw a comprehensive picture of diagnoses associated with AKI. Hospital stays for 126,736 unique individuals were extracted. Hemodynamic impairment and surgical procedures are the main factors associated with HA-AKI and five clusters of diagnoses were identified: sepsis, heart diseases, polytrauma, liver disease, and cardiovascular surgery. The ICD-10 code co...Continue Reading

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Citations

Oct 13, 2017·QJM : Monthly Journal of the Association of Physicians·J HolmesUNKNOWN Welsh AKI Steering Group
Sep 14, 2019·Pharmacoepidemiology and Drug Safety·Joël CosteMahmoud Zureik
Jan 18, 2018·Physiological Genomics·Michael HultströmSofia Jönsson
Nov 10, 2018·BMC Nephrology·Joel Neugarten, Ladan Golestaneh
Jan 26, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Dana Fuhrman
Apr 10, 2019·Deutsches Ärzteblatt International·Mark Dominik AlscherMartin K Kuhlmann

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