The diagnostic accuracy of imaging modalities to detect pseudarthrosis after spinal fusion-a systematic review and meta-analysis of the literature

Skeletal Radiology
Marloes J M PetersPaul C Willems

Abstract

The aim of the study was to determine the diagnostic accuracy of imaging modalities to detect pseudarthrosis after thoracolumbar spinal fusion, with surgical exploration as reference standard. A systematic literature search for original studies was performed on the diagnostic accuracy of imaging as index test compared to surgical exploration as reference standard to diagnose pseudarthrosis after thoracolumbar spinal fusion. Diagnostic accuracy values were extracted and methodologic quality of studies was evaluated by the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool. Per modality, clinically comparable studies were included in subgroup meta-analysis and weighted odds ratios (ORs) were calculated using the random effects model. Fifteen studies were included. Risk of bias was classified as high/unclear in 58% of the studies. Concerns of applicability was classified as high/unclear in 40% of the studies. Four scintigraphy studies including 93 patients in total were pooled to OR = 2.91 (95% confidence interval [CI]: 0.93-9.13). Five studies on plain radiography with 398 patients in total were pooled into OR = 7.07 (95% CI: 2.97-16.86). Two studies evaluating flexion-extension radiography of 75 patients in tota...Continue Reading

References

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Citations

Jun 4, 2020·Skeletal Radiology·William PalmerChristian W A Pfirrmann
Oct 13, 2020·Revista española de medicina nuclear e imagen molecular·E Noriega-ÁlvarezR García Jiménez
Mar 1, 2021·The Spine Journal : Official Journal of the North American Spine Society·Elizabeth P NorheimKern H Guppy
Sep 30, 2020·Clinical Spine Surgery : a Spine Publication·Sean PirkleMichael J Lee
May 6, 2021·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Manuel Fernandes MarquesUNKNOWN Société Française de Chirurgie Rachidienne, SFCR

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Methods Mentioned

BETA
RSA

Software Mentioned

Quality Assessment for Diagnostic Accuracy Studies 2 ( QUADAS ...
Stata
QUADAS

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