The diagnostic and prognostic role of myocardial injury biomarkers in hospitalized patients with COVID-19

Clinica Chimica Acta; International Journal of Clinical Chemistry
Pingji DengLeyong Yuan

Abstract

The aim of this study was to systematically and comprehensively evaluate the diagnostic and prognostic value of myocardial injury biomarkers in COVID-19 patients. This is a retrospective cohort study of confirmed COVID-19 patients that were admitted to the Renmin Hospital of Wuhan University from January 30, 2020 to February 15, 2020. Receiver operating characteristic (ROC) curve analysis demonstrated that cTnI-ultra had the highest area under the curve (AUC) at 0.855, with a sensitivity of 67.3% and a specificity of 88.7% for the prediction of in-hospital mortality. Patients with higher troponin I-ultra (cTnI-ultra), creatinine kinase-myocardial band (CK-MB), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were associated with higher mortality, compared to those who lower levels. The multivariable cox regression indicated that age (hazard ratio (HR) 3.450, 95% confidence interval (CI) 1.627-7.314, P = 0.001), coronary heart disease (HR 1.855, 95% CI 1.006-3.421; P = 0.048), elevated cTnI-ultra (HR 3.083, 95% CI 1.616-5.883, P = 0.001), elevated CK-MB (HR 2.907, 95% CI 1.233-6.854; P = 0.015), and elevated NT-proBNP (HR 5.776, 95% CI 2.272-14.682; P < 0.001) were associated with in-hospital mortality. cTnI-ultra might...Continue Reading

Citations

Sep 16, 2020·Medicina·Allison B ReissEric R Goldberg
Jan 10, 2021·European Journal of Heart Failure·Juan Caro-CodónUNKNOWN CARD-COVID Investigators
Feb 23, 2021·Revista Española De Cardiología·Francesco CannataGiulio G Stefanini
Feb 27, 2021·Medicina clínica·Chendi LiangGang Qin
Mar 9, 2021·Revista española de cardiología·Francesco CannataGiulio G Stefanini
Mar 13, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Citrawati Dyah Kencono Wungu Soetjipto
Jun 11, 2021·Medicina Clínica·Chendi LiangGang Qin
Aug 21, 2021·Journal of Infection and Public Health·Wen AnTae-Eun Kim

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