The diagnostic and prognostic roles of serum irisin in bladder cancer.

Current Problems in Cancer
Marwa M Esawy, Khalid M Abdel-Samd

Abstract

Egypt is among the countries with the highest incidence of bladder cancer (BC). Adipokines involved in BC development. This study aimed to examine the diagnostic and prognostic roles of irisin in BC through its function as an adipokine. This study included 150 subjects; 75 patients newly diagnosed as BC and 75 apparently healthy subjects. Serum irisin levels were quantified by enzyme-linked immunosorbent assay. Serum irisin levels exhibited significantly lower levels in BC patients compared to controls (1.07 [0.51-1.96] and 1.8 [0.5-2.44] µg/mL), respectively (P < 0.001). Serum irisin was positively correlated with BMI (r = 0.386, P = 0.001) and negatively correlated with serum cholesterol (r = -0.58, P < 0.0001). Irisin had 74.7% sensitivity and 90.7% specificity at a cutoff point of ≤1.2 µg/mL. Serum irisin levels reduction can predict the BC stages, when adjusted for BMI and serum cholesterol level, serum irisin had an adjusted odds ratio of 14 (P = 0.001). Low serum irisin patients had a higher mortality rate when compared to those with high levels (38.2% vs 5%). BC patients had significantly lower levels of serum irisin. Serum irisin showed acceptable performance criteria in BC diagnosis. It had a limited role in BC gradin...Continue Reading

Citations

Jun 18, 2020·OncoTargets and Therapy·Deguo ZhangGuangjun Shi
Mar 11, 2021·International Journal of Endocrinology·Grigorios PanagiotouEleni Papakonstantinou
Jun 3, 2021·Cancers·Evangelia TsianiPanagiota Klentrou
Jul 3, 2021·Cells·Agnieszka PinkowskaKatarzyna Nowińska
Jul 24, 2021·Journal of Proteomics·Rubén López-CortésCristina Núñez

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