The diagnostic dilemma of primary central nervous system melanoma

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Tabassum WadasadawalaRakesh Jalali

Abstract

Melanomas are malignant neoplasms of melanocytes developing predominantly in the skin, but occasionally arising from eyes, mucous membranes, and the central nervous system (CNS). The CNS can be affected by a spectrum of melanocytic lesions ranging from diffuse neurocutaneous melanosis, to a focal and benign neoplasm (melanocytoma), and to an overtly malignant tumor (melanoma). Primary melanocytic lesions involving the CNS are typically concentrated in the perimedullary and high cervical region. Primary CNS melanoma cannot be reliably distinguished from metastatic melanoma on neuroimaging and histopathological characteristics alone: its diagnosis is established only after exclusion of secondary metastatic disease from a cutaneous, mucosal or retinal primary. We present two patients with primary CNS melanoma and discuss relevant issues, available treatment options, and expected outcomes. Awareness of disease spectrum and clinico-biological differences may be used to guide therapeutic decision-making for a patient with a proven or suspected primary CNS melanoma.

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Citations

Dec 12, 2012·Surgical Neurology International·Yoshinari ShinsatoKazunori Arita
Dec 18, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Zhao-Yu XieChen-Hsi Hsieh
Nov 6, 2014·Surgical Neurology International·Victoria TrinhMuhammad O Chohan
Mar 24, 2012·AJNR. American Journal of Neuroradiology·G Q HouX L Zhang
Dec 16, 2011·Journal of Neuroradiology. Journal De Neuroradiologie·L MondotS Chanalet
Mar 26, 2013·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Cona C AnwerErik R Wisner
Dec 19, 2013·Brain Pathology·Marian C NeidertOguzkan Sürücü
May 27, 2014·Neuro-Chirurgie·A Y LuK R Bulsara
Aug 22, 2015·Case Reports in Oncological Medicine·Rajesh BalakrishnanSamson S K Gaddam
Sep 3, 2016·World Journal of Surgical Oncology·Marta Troya-CastillaFrancisco Javier Márquez-Rivas
Jan 21, 2017·Journal of Neurosurgery·Yislenz Narváez-MartínezMaria Teresa Fernandez-Figueras
Nov 22, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathryn E SomersNimish A Mohile
Mar 17, 2017·AJR. American Journal of Roentgenology·Vincenzo K WongPerry J Pickhardt
Mar 14, 2013·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Hong Je LeeJaetae Lee
Nov 7, 2019·BMC Neurology·Tomasz GarbaczHalina Bartosik-Psujek
Jan 7, 2017·Journal of Korean Neurosurgical Society·Kengo HirotaHidetoshi Kasuya
Apr 4, 2021·Healthcare·Alfonso MaiellaroGiuseppe Vacchiano

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