The Diagnostic Performance of Minimally Invasive Biopsy in Predicting Breast Pathological Complete Response After Neoadjuvant Systemic Therapy in Breast Cancer: A Meta-Analysis

Frontiers in Oncology
Yan LiQiang Sun

Abstract

Background: Neoadjuvant systemic therapy (NST) is commonly used in patients with early stage breast cancer before definitive surgery. The standard diagnostic approach for pathologic complete response (pCR) of the breast is breast surgery and pathologic examination. In recent years, several trials investigated the predictive value of image-guided minimally invasive biopsy (MIB) for breast pCR after NST. This study conducted a meta-analysis to evaluate the diagnostic accuracy of MIB. Materials and Methods: We identified relevant research reports in online databases through February 2020. The Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool was used to evaluate the quality of included trials. We extracted relevant data and constructed a 2 × 2 contingency table to analyze the predictive accuracy of MIB for breast pCR. Subgroup analyses and meta-regressions were also performed to investigate potential causes of heterogeneity. Results: Nine trials (with 1,030 breast cancer patients) were included in this meta-analysis. The pooled sensitivity and specificity of MIB were 0.72 [95% confidence interval (CI): 0.61-0.81] and 0.99 (95% CI: 0.89-1.00), respectively. By combining relevant data, there were no significant dif...Continue Reading

References

Jan 24, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P EllisJ McKinna
Dec 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A RingI E Smith
Jul 8, 2010·International Journal of Radiation Oncology, Biology, Physics·Caroline DaveauMarc A Bollet
May 20, 2014·The British Journal of Surgery·S KümmelS Loibl
Oct 29, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alfredo BerrutiMaria Pia Sormani
Mar 10, 2016·Breast Cancer Research : BCR·Raquel F D van la Parra, Henry M Kuerer
Nov 5, 2016·AJR. American Journal of Roentgenology·Gaiane M RauchWei Tse Yang
Nov 9, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Joerg HeilMichael Golatta
Mar 13, 2017·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M Teshome, H M Kuerer
Apr 7, 2017·Oncology Reviews·Aurelio Bartolome CastrellonLuis Estuardo Raez
Jun 1, 2017·The New England Journal of Medicine·Norikazu MasudaMasakazu Toi
Oct 19, 2017·Radiology·Amy M FowlerBonnie N Joe
May 15, 2018·The Breast : Official Journal of the European Society of Mastology·Huimin LiKehu Yang
Dec 6, 2018·The New England Journal of Medicine·Gunter von MinckwitzUNKNOWN KATHERINE Investigators
Jun 16, 2019·Breast Cancer Research : BCR·Richard J BownesOlga Oikonomidou
Oct 23, 2019·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Sarah L SavaridasAndy Evans
Dec 2, 2019·The Breast : Official Journal of the European Society of Mastology·Roberto Lo GulloKatja Pinker

❮ Previous
Next ❯

Citations

Oct 14, 2020·Annals of Surgical Oncology·Makoto Ishitobi, Naoki Hayashi
Jun 25, 2021·The Breast : Official Journal of the European Society of Mastology·Monika GraeserUlrike Nitz
Jul 3, 2021·Expert Review of Anticancer Therapy·Gianluca FranceschiniRiccardo Masetti

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

QUADAS
Revman calculator
Quality Assessment of Diagnostic Accuracy Studies 2 ( QUADAS -...
Disc
Stata
Meta
RevMan

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.