The diagnostic significance of immunoglobulin and fibrin deposition in lichen planus.

The British Journal of Dermatology
E AbellD Ramnarain

Abstract

Direct immunofluorescent (IF) staining was performed on biopsy specimens from fifty-three patients with active lichen planus. In fifteen of these cases uninvolved skin sites were also examined. Globular or cytoid body-like deposits of immunoglobulins, mainly IgM, were detected in forty-six of the active lesions, and in half the uninvolved skin biopsies. The deposition of fibrin in the papillary dermis and around follicular structures was seen only in the active lichen planus papules. The significance of these findings was assessed by comparison with the IF results obtained in 252 biopsies from various cutaneous disorders, stained by the same technique during the period of this study. Although the presence of immunoglobulin cytoid bodies and fibrin was found to be highly characteristic of lichen planus, these findings were not specifically diagnostic. Morphologically identical deposits were seen not infrequently in lupus erythematosus and in eczema. Active lesions of dermatitis herpetiformis, erythema multiforme and other rare dermatoses also showed these cytoid body-like immunoglobulin deposits.

References

Jan 1, 1972·Dermatologica·R K WinkelmannJ M de Moragas
Feb 1, 1966·Arthritis and Rheumatism·E M Tan, H G Kunkel
May 1, 1968·Archives of Dermatology·E L Pohle, D L Tuffanelli
Mar 1, 1972·The British Journal of Dermatology·M M Black
Apr 1, 1974·The British Journal of Dermatology·E H de la Faille-Kuyper, H B de la Faille
Jan 1, 1973·The British Journal of Dermatology·R MarksE W Jones

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Citations

Jan 1, 1985·Archives of Dermatological Research·Y HoriguchiS Imamura
Jan 1, 1989·Archives of Dermatological Research·K Ito, K Hashimoto
Jun 1, 1977·Clinical and Experimental Dermatology·R S Rogers, R E Jordon
Dec 1, 1977·Clinical and Experimental Dermatology·M M Black
Dec 1, 1977·Clinical and Experimental Dermatology·H Ebner, W Gebhart
Mar 1, 1978·Clinical and Experimental Dermatology·W K Jacyk, B M Greenwood
Sep 1, 1979·International Journal of Dermatology·A Taaffe
Jun 1, 1996·International Journal of Dermatology·A S al-FouzanA I Rostom
Mar 21, 1998·Journal of Cutaneous Pathology·H Biermann, E W Rauterberg
Aug 1, 1990·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·N A FirthP C Reade
Mar 11, 1978·British Medical Journal·A TaaffeR Marks
Jun 1, 1977·Journal of Clinical Pathology·S Shousha, J Svirbely
Dec 1, 1978·Journal of Clinical Pathology·W K BlenkinsoppG P Haffenden
Jul 27, 2010·Indian Journal of Dermatology, Venereology and Leprology·Leena ChularojanamontriKanokvalai Kulthanan
Aug 7, 2013·Indian Journal of Dermatology·Tanwar PranaySeema Chhabra
Jan 1, 1978·The Journal of Dermatologic Surgery and Oncology·R J Gorlin, H O Sedano
Jun 1, 1982·The British Journal of Dermatology·R A Graham-BrownS Sherlock
Aug 1, 1978·Journal of Cutaneous Pathology·T PiamphongsantP Kullavanijaya
Apr 1, 1979·The British Journal of Dermatology·J Clarke, M M Black
Jun 1, 1979·The British Journal of Dermatology·S HalevyE J Feuerman
Aug 1, 1979·The British Journal of Dermatology·D Weedon, E Shand
Feb 1, 1977·The British Journal of Dermatology·M G DaviesR Marks
Jun 1, 1977·The British Journal of Dermatology·D M MacDonaldN Ramnarain
Dec 1, 1985·Journal of the American Academy of Dermatology·P DuschetF Gschnait
Aug 1, 1982·Journal of the American Academy of Dermatology·R T HornM A Guill
Jun 1, 1992·Journal of the American Academy of Dermatology·S C LinC P Chiang
Sep 1, 1979·Journal of the American Academy of Dermatology·K KonradK Holubar
Oct 1, 1984·Journal of the American Academy of Dermatology·W KorkijK Soltani
Jun 1, 1981·Oral Surgery, Oral Medicine, and Oral Pathology·M SchiødtS Ullman
Aug 1, 1985·Scandinavian Journal of Dental Research·K PihlmanT Reunala
Mar 1, 1980·International Journal of Dermatology·B L Maltz, L E Becker
Feb 1, 1982·The British Journal of Dermatology·K Danno, S Imamura
Dec 1, 1981·Journal of Oral Pathology·G LaskarisA Angelopoulos
Jan 1, 1986·Clinical and Experimental Dermatology·R H Meyrick Thomas, D D Munro
Jun 1, 1986·The Journal of Dermatology·T Horio, S Imamura
Apr 1, 1986·The British Journal of Dermatology·F C PowellS B Moore
Feb 1, 1980·The British Journal of Dermatology·K DannoS Ofuji
Apr 1, 1981·The British Journal of Dermatology·K Danno, T Horio
Mar 1, 1986·Clinical and Experimental Dermatology·M H Rustin, D D Munro
Jul 1, 1985·International Journal of Dermatology·E H Beutner, V Kumar
Jul 1, 1978·Oral Surgery, Oral Medicine, and Oral Pathology·J A RegeziJ R Hayward
Jan 1, 1981·Oral Surgery, Oral Medicine, and Oral Pathology·T E Daniels, C Quadra-White
Jun 1, 1991·International Journal of Oral and Maxillofacial Surgery·P Jungell
May 1, 1982·Oral Surgery, Oral Medicine, and Oral Pathology·G LaskarisA Angelopoulos
Jul 13, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Yi-Shing Lisa ChengSusan Muller

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