The diagnostic significance of liver cell inhomogeneity: serum enzymes in patients with central liver necrosis and the distribution of glutamate dehydrogenase in normal human liver.

Zeitschrift Für Klinische Chemie Und Klinische Biochemie
W G GuderO H Wieland

Abstract

16 Patients with acute right-sided cardiac failure associated with a high pressure of the central venous system, exhibited a marked increase in glutamate dehydrogenase activity in serum. This increase was 40-fold higher than in patients with acute viral hepatitis. Histological examination of seven deceased patients revealed central necrosis within the liver lobule. This observation led us to determine glutamate dehydrogenase activity in microdissected peripheral and central portions from the unchanged liver lobule. A 1.7-fold higher glutamate dehydrogenase activity was found in the central part of the liver lobule than in the peripheral portion. The diagnostic significance of the glutamate dehydrogenase activity distribution along the cords of liver cells is discussed in view of liver diseases with central necrosis.

References

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Citations

May 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·G M GroothuisM J Hardonk
Dec 1, 1988·Digestive Diseases and Sciences·J J Reichling, M M Kaplan
Mar 31, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·E S Schmidt, F W Schmidt
Feb 22, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·J WeillA M Le Goff
Dec 15, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·F W Schmidt, E Schmidt
Feb 28, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·M L GozzoM Castagneto
Aug 1, 1993·Clinical Biochemistry·E Schmidt, F W Schmidt
Jan 1, 1982·Transactions of the Royal Society of Tropical Medicine and Hygiene·M M MansourR H Watten
Jul 1, 1988·Journal of Comparative Pathology·C W DavyD A Eichler

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