The diagnostic significance of single or combination lung cancer-related serum biomarkers in high risk lung cancer patients

Zhonghua nei ke za zhi
Jun NiLi Zhang

Abstract

The aim of this study was to assess the clinical value of pro-gastrin releasing peptide (ProGRP), squamous cell carcinoma antigen (SCC-Ag), cytokeratin 19 fragment antigen 21-1(Cyfra21-1) and carcino-embryonic antigen (CEA ) in the diagnosis and clinical stage of lung cancer in Chinese patients. Patients with lung cancer and benign lesions confirmed by pathology were enrolled in Peking Union Medical College Hospital from January 2013 to October 2014. The serum levels of four tumor markers (ProGRP, SCC-Ag, Cyfra21-1 and CEA) were measured using immunoassays before treatment.The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and the areas under the receiver operating characteristic curve (AUCROC) of these four tumor biomarkers were analyzed for the diagnosis of lung cancer. A total of 134 patients were finally analyzed, including 73 patients with lung cancer and the other 61 patients with benign lung disease.The diagnostic sensitivity of serum Cyfra21-1 to lung cancer was 67.1%, the specificity 45.1%, the AUCROC 0.658.The diagnostic sensitivity of the panel including ProGPR, Cyfra21-1 and CEA to lung cancer was 75.3%, the specificity 57.4%, the AUCROC 0.702. In the lung cancer group, th...Continue Reading

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